Visao Geral Kisspeptin refers to a family of neuropeptides derivado(a) de the KISS1 gene, originally descoberto(a) em 1996 by Danny R. Welch and J.H. Lee in Hershey, Pennsylvania, como um(a) melanoma metastasis suppressor. The gene was named "KiSS-1" to honor the discovery location near the Hershey's Kisses chocolate factory, with "SS" denoting "suppressor sequence."[1] The KISS1 gene encodes a 145-aminoacido prepro-kisspeptin precursor que undergoes proteolytic cleavage to produce four biologic

How does Kisspeptin work? What is its mechanism of action?

Mecanismo de Acao KISS1R (GPR54) Receptor Binding Kisspeptin acts by binding KISS1R (GPR54/AXOR12), a rhodopsin-like Class A GPCR sharing ~45% identity with galanin receptors (but nao bind galanin). The essencial pharmacophore e o(a) C-terminal RF-amide motif; key residues Phe-6 and Arg-9 (Kp-10 numbering) are critico(a) para binding. Cryo-EM studies reveal an orthosteric pocket spanning TM2–7 plus ECL1–3.[2][3] Primary Gαq/11–PLC–Ca²⁺ Pathway KISS1R couples primariamente to Gαq/11, activating p

What are the research applications of Kisspeptin?

Aplicacoes de Pesquisa Kisspeptin is one do(a) a maioria extensively studied reproductive neuropeptides, with >1,000 human subjects across Phase 1/2 ensaios clinicos: IVF Oocyte Maturation Trigger — Kp-54 has been studied as an oocyte-maturation trigger in IVF cohorts; oocyte-maturation, live-birth and OHSS endpoints are reported in the cited references.[10][11] Hypothalamic Amenorrhea — LH-pulsatility endpoints reported over an 8-week study.[12][13][19] PCOS — LH and estradiol endpoints were re

What does the research summary say about Kisspeptin?

Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Mills et al. (2025)C57BL/6J mice — Kp-5412.8–50 nM: dose-dependente LH to 3.6 ng/mL at 25 min (p [19] Izarraras et al. (2025)DIAMOND mice — TAK-448 MASLD0.3 nmol/h × 6 weeks: reduziu liver triglycerides, serum FFA, ALT (p [18] Seminara/Ramaswamy (2006/07)Juvenile rhesus monkeys — IV KP-10200–400 µg/h × 98h: maximal LH at 3h, dessensibilizacao by 12h; GnRH bolus still eficaz but KP-10 bolus was not[23] Terse

How should Kisspeptin be stored?

Armazene liofilizado kisspeptin a −20°C. Evite congelamento-descongelamento repetido.

Kisspeptin: Chemical Properties

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30 Citacoes PubMedRevisado por EspecialistasUltima Revisao: fevereiro de 2026

Propriedades Quimicas

Gene	KISS1 (chromosome 1q32, human)
Precursor Size	145 aminoacidos (prepro-kisspeptin)
Molecular Weight (Kp-54)	~5.9 kDa
Molecular Weight (Kp-10)	~1.3 kDa
Sequence (Kp-10, Human)	YNWNSFGLRF-NH₂ (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂)
Sequence (Kp-10, Rodent)	YNWNSFGLRY-NH₂
C-Terminal Motif	RF-amide (Arg-Phe-NH₂) — critico(a) para KISS1R binding
Receptor	KISS1R (GPR54/AXOR12) — Class A rhodopsin-like GPCR
Isoforms	Kp-54, Kp-14, Kp-13, Kp-10 (all share C-terminal decapeptide)
Synonyms	Metastin, KiSS-1-derived peptide, Kp-54, Kp-14, Kp-13, Kp-10
Analogs	MVT-602 (TAK-448), TAK-683
Plasma Half-Life	Kp-10 ~4 min; Kp-54 ~27.6 min; MVT-602 peaks at 21h

Identificadores

Purity Standard	≥97% by RP-HPLC
Identity Confirmation	Não informado no certificado de lote publicado
Endotoxin	Negative by LAL assay
Sterility	Não informado no certificado de lote publicado

Editorial Research Note

“Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Mills et al.”

Pure U.S. Peptides Research Standards TeamInternal editorial group summarising published peptide research for an audience of qualified independent investigators.

Referencias

Perguntas de Pesquisa Relacionadas

→ What Is Kisspeptin?→ Kisspeptin: Mechanism of Action → Kisspeptin: Research Applications → Kisspeptin: Safety Profile & Research Summary → Storing Kisspeptin: Best Practices

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Este conteudo e fornecido apenas para fins educacionais e informativos. Os produtos sao fornecidos apenas para estudos in vitro e nao sao medicamentos, drogas ou suplementos. Nao aprovado pela FDA para prevenir, tratar ou curar qualquer condicao.