Oxytocin: Chemical Properties
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Comprar péptido Oxytocin 10mg24 Citas PubMedRevisado por EspecialistasÚltima Revisión: febrero de 2026
Propiedades Químicas
| Molecular Formula | C₄₃H₆₆N₁₂O₁₂S₂ |
| Molecular Weight | 1007.19 g/mol |
| CAS Number | 50-56-6 |
| PubChem CID | 439302 |
| Sequence | Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH₂ |
| Structure | Nonapéptido cíclico; puente disulfuro Cys¹-Cys⁶; amida primaria en el extremo C-terminal |
| InChI Key | XNOPRXBHLZRZKH-DSZYJQQASA-NY |
| Synonyms | 'hormona del amor' |
| Gene | OXT (cromosoma 20) |
| Precursor | Preprooxitocina (incluye la proteína transportadora neurofisina I) |
| Activity | 1 Unidad USP ≈ 1,68 µg de péptido puro |
| Plasma Half-Life | ~3–5 min (plasma); ~28 min (LCR) |
Identificadores
| Purity Standard | Certificado de lote pendiente |
| Identity Confirmation | Certificado de lote pendiente |
| Counter-Ion | No informado en el certificado de lote publicado |
| Preservatives | Clorobutanol 0,5%, tampón de ácido acético (pH 3,0–5,0) |
Editorial Research Note
“Resumen de Investigación Preclínica Estudios Preclínicos Clave EstudioModeloHallazgos ClaveRef Shin et al.”
Referencias
- du Vigneaud V, Ressler C, Trippett S. The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin. Journal of Biological Chemistry. 1953;205(2):949-957.
- du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG, Gordon S. The synthesis of an octapeptide amide with the hormonal activity of oxytocin. Journal of the American Chemical Society. 1953;75(19):4879-4880.
- Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiological Reviews. 2001;81(2):629-683.
- Salati JA, Leathersich SJ, Williams MJ, Cuthbert A, Tolosa JE. Cochrane Database of Systematic Reviews. 2019;4(4):CD001808.
- Young LJ, Wang Z. The neurobiology of pair bonding. Nature Neuroscience. 2004;7(10):1048-1054.
- Gutkowska J, Jankowski M. Oxytocin revisited: its role in cardiovascular regulation. Journal of Neuroendocrinology. 2012;24(4):599-608.
- Zhang Y, Zhang X, Huang L. Frontiers in Psychiatry. 2025;15:1477076.
- Sikich L, Kolevzon A, King BH, et al. New England Journal of Medicine. 2021;385(16):1462-1473.
- Plessow F, Kerem L, Wronski ML, et al. NEJM Evidence. 2024;3:EVIDoa2300349.
- Espinoza SE, Lee JL, Wang CP, et al. Journal of the American Medical Directors Association. 2021;22(9):1877-1882.e2.
- Giannoulis E, Andreini E, Santambrogio J, et al. The interplay between borderline personality disorder and oxytocin. Brain Sciences. 2025.
- Petersson M, Alster P, Lundeberg T, Uvnas-Moberg K. Oxytocin causes a long-term decrease of blood pressure in female and male rats. Physiology & Behavior. 1996;60(5):1311-1315.
- Hollander E, Jacob S, Engel A, et al. Journal of Psychiatric Research. 2021;142:311-318.
- Elabd C, Cousin W, Upadhyayula P, et al. Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Nature Communications. 2014;5:4082.
- Onuc ME, et al. Psychiatry International. 2025.
- Shin H, et al. Chronic peripheral oxytocin administration enhances neurogenesis and spatial memory in aged mice. 2025.
- Chavez CM, et al. Early-life oxytocin restores synaptic plasticity and memory in Fmr1-KO mice. 2024.
- Blevins JE, Graham JL, Morton GJ, et al. American Journal of Physiology. 2015;308(5):R431-R438.
- Marlin BJ, Mitre M, D'amour JA, Chao MV, Bhatt D, Bhatt R, Bhatt DL, Bhatt DL, Froemke RC. Oxytocin enables maternal behaviour by balancing cortical inhibition. Nature. 2015;520(7548):499-504.
- Szeto A, Nation DA, Mendez AJ, et al. Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. American Journal of Physiology. 2008;295(6):E1495-E1501.
- Rajamannar P, Blechman J, Raz O, Levkowitz G. Neuropeptide oxytocin facilitates its own brain-to-periphery uptake. Cell Reports. 2025;44(4):115491.
- Lawson EA. Nature Reviews Endocrinology. 2017;13(12):700-709.
- Blevins JE, Baskin DG. Physiology & Behavior. 2015;152(Pt B):438-449.
- Insel TR. Is social attachment an addictive disorder? Physiology & Behavior. 2003;79(3):351-357.
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