PT-141: Chemical Properties
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Buy PT-141 Peptide 10mg (Bremelanotide)24 PubMed CitationsExpert ReviewedLast Reviewed: July 2026
Chemical Properties
| Molecular Formula | C₅₀H₆₈N₁₄O₁₀ |
| Molecular Weight | 1025.2 g/mol |
| CAS Number | 189691-06-3 |
| PubChem CID | 9941379 |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Structure | Cyclic heptapeptide; lactam bridge between Asp and Lys side chains; D-Phe substitution; N-acetylated norleucine; C-terminal free acid |
| Parent Molecule | α-MSH analogue; deaminated derivative of Melanotan II |
| Synonyms | Bremelanotide, PT-141, PT-141 free base |
| Class | Synthetic cyclic peptide; non-selective melanocortin receptor agonist |
| Regulatory Status | Research-grade material supplied for laboratory use only; a separate pharmaceutical formulation of bremelanotide holds FDA approval |
Identifiers
| InChI Key | FFHBJDQSGDNCIV-MFVUMRCOSA-N |
| Isomeric SMILES | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)O)NC(=O)C |
| Exact Mass | 1024.5243 Da (monoisotopic) |
| Purity Standard | ≥98% by RP-HPLC |
| Identity Confirmation | Lot certificate pending |
| Detection Methods | RP-HPLC, UHPLC-MS/MS, LC-HRMS/MS |
Editorial Research Note
“Research Summary Foundational and Mechanistic Studies StudyTypeSubject of ReportRef Molinoff et al.”
References
- Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY. Ann N Y Acad Sci. 2003;994:96-102.
- Hadley ME, Dorr RT. Peptides. 2006;27(4):921-930.
- Van der Ploeg LH, Martin WJ, Howard AD, et al. Proc Natl Acad Sci U S A. 2002;99(17):11381-11386.
- Zhang H, Chen LN, Yang D, et al. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res. 2021;31(11):1163-1175.
- Yuan XC, Tao YX. Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin. Biomolecules. 2022;12(10):1407.
- Sweeney P, Gimenez LE, Hernandez CC, Cone RD. Nat Rev Endocrinol. 2023;19(9):507-519.
- Giuliano F. J Androl. 2004;25(5):683-691.
- Pfaus JG, Shadiack A, Van Soest T, Tse M, Molinoff P. Proc Natl Acad Sci U S A. 2004;101(27):10201-10204.
- Pfaus J, Giuliano F, Gelez H. J Sex Med. 2007;4 Suppl 4:269-279.
- Shadiack AM, Sharma SD, Earle DC, Spana C, Hallam TJ. Curr Top Med Chem. 2007;7(11):1137-1144.
- Shadiack AM, Althof S. Int J Impot Res. 2008;20 Suppl 1:S11-S16.
- Pfaus JG, Sadiq A, Spana C, Clayton AH. CNS Spectr. 2022;27(3):281-289.
- Dhillon S, Keam SJ. Drugs. 2019;79(14):1599-1606.
- White WB, Myers MG, Jordan R, Lucas J. Usefulness of ambulatory blood pressure monitoring to assess the melanocortin receptor agonist bremelanotide. J Hypertens. 2017;35(4):761-768.
- Sauter M, Uhl P, Burhenne J, Haefeli WE. J Pharm Biomed Anal. 2020;186:113276.
- Yuvaraaj VK, Sharma N. Comprehensive characterization of bremelanotide acetate and its degradants by LC-HRMS/MS and predicting epimerization through computational modelling. Anal Methods. 2026.
- Mestria S, Odoardi S, Frison G, Strano Rossi S. Drug Test Anal. 2021;13(4):876-882.
- Suzuki S, Kitanaka C, Okada M. Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma Cells via Suppression of Survivin Expression. Anticancer Res. 2024;44(9):3875-3883.
- Borland JM, Kohut-Jackson AL, Peyla AC, Hall MA, Mermelstein PG, Meisel RL. Neuropharmacology. 2025;267:110299.
- Merlino F, Jia L, Boccino I, et al. J Med Chem. 2026.
- Bardhan M, Anand A, Javed A, et al. Polymorphism of Melanocortin Receptor Genes-Association with Inflammatory Traits and Diseases. Diseases. 2025;13(9):305.
- Spielmans GI. J Sex Res. 2021;58(9):1085-1105.
- J Urol. 2023 Jan 10.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 9941379, Bremelanotide. PubChem. Accessed 2026-07-31.
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