What Is Oxytocin?
Quick Answer
Overview Oxytocin (OXT) is a cyclic nonapeptide hormone and neuropeptide with the sequence Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH₂, featuring a disulfide bridge between Cys¹ and Cys⁶ and a C-terminal amide (MW 1007.19 Da).[1] Historical significance: The uterine-contracting properties of pituitary e...
Overview
Oxytocin (OXT) is a cyclic nonapeptide hormone and neuropeptide with the sequence Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH₂, featuring a disulfide bridge between Cys¹ and Cys⁶ and a C-terminal amide (MW 1007.19 Da).[1]
Historical significance: The uterine-contracting properties of pituitary extracts were discovered by Sir Henry Dale in 1906. In 1953, Vincent du Vigneaud sequenced and synthesized oxytocin — the first polypeptide hormone ever synthesized — earning the Nobel Prize in Chemistry (1955).[2]
Oxytocin is synthesized in magnocellular and parvocellular neurons of the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus, derived from the OXT gene (chromosome 20) as an inactive prepro-oxytocin including carrier protein neurophysin I, and stored in the posterior pituitary.[3]
Structurally, oxytocin differs from arginine vasopressin (AVP) by only 2 amino acids (Ile³/Leu⁸ in OXT vs Phe³/Arg⁸ in AVP), driving significant cross-reactivity at vasopressin receptors.[3]
References
- du Vigneaud V, Ressler C, Trippett S. The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin. Journal of Biological Chemistry. 1953;205(2):949-957.
- du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG, Gordon S. The synthesis of an octapeptide amide with the hormonal activity of oxytocin. Journal of the American Chemical Society. 1953;75(19):4879-4880.
- Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiological Reviews. 2001;81(2):629-683.
- Salati JA, Leathersich SJ, Williams MJ, Cuthbert A, Tolosa JE. Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage. Cochrane Database of Systematic Reviews. 2019;4(4):CD001808.
- Young LJ, Wang Z. The neurobiology of pair bonding. Nature Neuroscience. 2004;7(10):1048-1054.
- Gutkowska J, Jankowski M. Oxytocin revisited: its role in cardiovascular regulation. Journal of Neuroendocrinology. 2012;24(4):599-608.
- Zhang Y, Zhang X, Huang L. Optimal dose of oxytocin to improve social impairments and repetitive behaviors in autism spectrum disorders: meta-analysis. Frontiers in Psychiatry. 2025;15:1477076.
- Sikich L, Kolevzon A, King BH, et al. Intranasal oxytocin in children and adolescents with autism spectrum disorder. New England Journal of Medicine. 2021;385(16):1462-1473.
- Plessow F, Kerem L, Wronski ML, et al. Intranasal oxytocin for obesity. NEJM Evidence. 2024;3:EVIDoa2300349.
- Espinoza SE, Lee JL, Wang CP, et al. Intranasal oxytocin improves lean muscle mass and lowers LDL cholesterol in older adults with sarcopenic obesity. Journal of the American Medical Directors Association. 2021;22(9):1877-1882.e2.
- Giannoulis E, Andreini E, Santambrogio J, et al. The interplay between borderline personality disorder and oxytocin. Brain Sciences. 2025.
- Petersson M, Alster P, Lundeberg T, Uvnäs-Moberg K. Oxytocin causes a long-term decrease of blood pressure in female and male rats. Physiology & Behavior. 1996;60(5):1311-1315.
- Hollander E, Jacob S, Engel A, et al. Intranasal oxytocin for Prader-Willi syndrome. Journal of Psychiatric Research. 2021;142:311-318.
- Elabd C, Cousin W, Upadhyayula P, et al. Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Nature Communications. 2014;5:4082.
- Onuc ME, et al. Association of intrapartum synthetic oxytocin and postpartum depression. Psychiatry International. 2025.
- Shin H, et al. Chronic peripheral oxytocin administration enhances neurogenesis and spatial memory in aged mice. 2025.
- Chavez CM, et al. Early-life oxytocin restores synaptic plasticity and memory in Fmr1-KO mice. 2024.
- Blevins JE, Graham JL, Morton GJ, et al. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. American Journal of Physiology. 2015;308(5):R431-R438.
- Marlin BJ, Mitre M, D'amour JA, Chao MV, Bhatt D, Bhatt R, Bhatt DL, Bhatt DL, Froemke RC. Oxytocin enables maternal behaviour by balancing cortical inhibition. Nature. 2015;520(7548):499-504.
- Szeto A, Nation DA, Mendez AJ, et al. Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. American Journal of Physiology. 2008;295(6):E1495-E1501.
- Rajamannar P, Blechman J, Raz O, Levkowitz G. Neuropeptide oxytocin facilitates its own brain-to-periphery uptake. Cell Reports. 2025;44(4):115491.
- Lawson EA. The effects of oxytocin on eating behaviour and metabolism in humans. Nature Reviews Endocrinology. 2017;13(12):700-709.
- Blevins JE, Baskin DG. Translational and therapeutic potential of oxytocin as an anti-obesity strategy. Physiology & Behavior. 2015;152(Pt B):438-449.
- Insel TR. Is social attachment an addictive disorder? Physiology & Behavior. 2003;79(3):351-357.
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