What Is Selank?
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Buy Selank Peptide 10mgQuick Answer
Overview Selank (TP-7) is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It was developed by the Institute of Molecular Genetics of the Russian Academy of Sciences in cooperation with the V.V. Zakusov Research Institute of Pharmacology.[2] Selank is derived from tu...
Selank — Quick Facts
| Molecular formula | C33H57N11O9 |
|---|---|
| Molecular weight | 751.9 g/mol |
| InChI key | JTDTXGMXNXBGBZ-YVHUGQOKSA-N |
| PubChem CID | 11765600 |
| Storage | Store lyophilized powder at 4°C, protected from light and moisture. |
| Cited references | 25 |
Chemical identity from PubChem CID 11765600. For research use only.
Overview
Selank (TP-7) is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It was developed by the Institute of Molecular Genetics of the Russian Academy of Sciences in cooperation with the V.V. Zakusov Research Institute of Pharmacology.[2]
Selank is derived from tuftsin (Thr-Lys-Pro-Arg), a naturally occurring tetrapeptide that constitutes a fragment of the heavy chain of human immunoglobulin G (IgG). The C-terminal Pro-Gly-Pro extension renders the molecule significantly more resistant to peptidase hydrolysis.[1]
In experimental contexts, Selank exhibits anxiolytic and nootropic effects comparable to classical benzodiazepines (such as diazepam) but without their characteristic negative observations — sedation, muscle relaxation, amnesia, dependence, or withdrawal syndrome.[5][6]
Regulatory records in the Russian Federation cite Selank's registration for research related to generalized anxiety disorders and neurasthenia.[3] It is not registered by the U.S. FDA, which has raised immunogenicity concerns related to compounding.[4]
Discovery and design rationale
The Selank molecule is the product of a structure-stabilization strategy applied to tuftsin, a phagocytosis-stimulating tetrapeptide originally isolated from the Fc region of IgG. While native tuftsin demonstrated immunomodulatory properties in preclinical work, its clinical utility was limited by rapid hydrolysis at the Lys–Pro and Pro–Arg bonds by serum aminopeptidases. Researchers at the Institute of Molecular Genetics appended the Pro-Gly-Pro tripeptide to the C-terminus — a motif also used in Semax and other Russian-developed regulatory peptides — to confer enzymatic resistance while preserving the bioactive N-terminal sequence.[1][2]
Research framework
Selank sits within an experimental class of "regulatory peptides" investigated in Eastern European pharmacology for nonsedating anxiolytic activity. In comparative preclinical literature it is studied alongside Semax (cognitive/neuroprotection), DSIP (sleep/HPA axis), and oxytocin (social/anxiolytic) for parallel CNS pharmacology paradigms.[7] The compound is supplied here strictly as a research reference standard for in vitro and animal-model investigation.
“Bodily introduction of any kind into humans or animals is strictly forbidden by law.”
References
- Kolomin TA, Shadrina M, Slominsky P, Limborska SA, Myasoedov NF. A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides. Neuroscience & Medicine. 2013;4(4):223–252.
- Vyunova TV, Andreeva LA, Shevchenko KV, Myasoedov NF. Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity. Protein & Peptide Letters. 2018;25(10):914–923.
- Medvedev VE, Tereshchenko ON, Kost NV, et al. Zhurnal Nevrologii i Psikhiatrii. 2015;115(6):33–40.
- U.S. Food and Drug Administration. Bulk Drug Substances Used in Compounding Under Section 503B. FDA Compounding Database. 2023.
- Zozulya AA, Neznamov GG, Syunyakov TS, et al. Zhurnal Nevropatologii i Psikhiatrii. 2008;108(4):38–48.
- Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neuroscience and Behavioral Physiology. 2003;33(7):639–643.
- Kolomin TA, Agapova T, Agniullin YV, et al. Changes in the Transcription Profile of the Hippocampus in Response to Administration of the Tuftsin Analog Selank. Neuroscience and Behavioral Physiology. 2014;44(8):849–855.
- V'yunova TV, Andreeva LA, Shevchenko KV, et al. Peptide regulation of specific ligand-receptor interactions of GABA with the plasma membranes of nerve cells. Neurochemical Journal. 2014;8(4):259–264.
- Volkova A, Shadrina M, Kolomin T, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Frontiers in Pharmacology. 2016;7:31.
- Kost NV, Sokolov OY, Gabaeva MV, et al. Russian Journal of Bioorganic Chemistry. 2001;27(3):180–183.
- Zozulya AA, Kost NV, Sokolov OY, et al. The Inhibitory Effect of Selank on Enkephalin-Degrading Enzymes as a Possible Mechanism of Its Anxiolytic Activity. Bull Exp Biol Med. 2001;131(4):315–317.
- Inozemtseva LS, Karpenko EA, Dolotov OV, et al. Doklady Biological Sciences. 2008;421:241–243.
- Narkevich VB, Kudrin VS, Klodt PM, et al. Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study. Eksperimental'naia i Klinicheskaia Farmakologiia. 2008;71(5):8-12.
- Uchakina ON, Uchakin PN, Miasoedov NF, et al. Zhurnal Nevrologii i Psikhiatrii. 2008;108(5):71–75.
- Kozlovskii II, Andreeva LA, Kozlovskaia MM, et al. The role of the opioid system in the anti-anxiety effect of the peptide anxiolytic selank. Eksperimental'naia i Klinicheskaia Farmakologiia. 2012;75(2):10-13.
- Kolik LG, Nadorova AV, Kozlovskaya MM. Bull Exp Biol Med. 2014;157(1):61–65.
- Konstantinopolsky MA, Kolik LG, Chernyakova IV. Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. Bull Exp Biol Med. 2022;173(6):730–733.
- Mukhina AY, Medvedeva OA, Svishcheva MV, et al. Bulletin of Experimental Biology and Medicine. 2019;167(2):226-228.
- Kasian A, Kolomin T, Andreeva L, et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behavioural Neurology. 2017;2017:5091027.
- Kolik LG, Nadorova AV, Antipova TA, Durnev AD. Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content. Bull Exp Biol Med. 2019;167(5):641–644.
- Medvedev VE, Tereshchenko ON, Israelian AI, et al. A comparison of the anxiolytic effect and tolerability of selank and phenazepam. Zhurnal Nevrologii i Psikhiatrii. 2014;114(7):17–22.
- Semenova TP, Kozlovskii II, Zakharova NM, Kozlovskaya MM. Experimental optimization of learning and memory processes by selank. Eksperimental'naia i Klinicheskaia Farmakologiia. 2010;73(8):2–5.
- Filatova E, Kasian A, Kolomin T, et al. GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Frontiers in Pharmacology. 2017;8:89.
- Kolomin TA, Shadrina M, Andreeva LA, et al. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regulatory Peptides. 2011;170(1-3):18–23.
- Andreeva LA, Nagaev IY, Mezentseva MV, et al. Antiviral properties of structural fragments of the peptide Selank. Doklady Biological Sciences. 2010;431:79–82.
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