Epithalon vs NAD+: Comparacao de Pesquisa em Longevidade
Quick Summary
Epithalon (Epitalon) e NAD+ representam duas abordagens fundamentalmente diferentes para pesquisa em longevidade. Epithalon, um tetrapeptideo desenvolvido pelo Prof. Vladimir Khavinson, ativa a telomerase para manter o comprimento dos telomeros — um marcador chave do envelhecimento biologico. NAD+ (nicotinamida adenina dinucleotideo) e uma coenzima critica para o metabolismo energetico celular e ativacao de sirtuinas. Ambos os compostos geraram interesse significativo na comunidade de pesquisa em biologia do envelhecimento.
Epithalon
Visao Geral da Pesquisa Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide geroprotector developed by Prof. Vladimir Khavinson no(a) St. Petersburg Institute of Bioregulacao and Gerontology como o(a) ativo(a) component of Epithalamin (bovine pineal gland extract). Its discovery originated from 1970s Soviet...
NAD+
Visao Geral NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every living cell, serving a dual function como um(a) electron transporter in redox reactions (glycolysis, TCA cycle → ATP production) e um(a) critical substrate for non-redox signaling enzymes incluindo...
Research Comparison: Epithalon vs NAD+
| Dimension | Epithalon | NAD+ |
|---|---|---|
| Estrutura | Tetrapeptideo (Ala-Glu-Asp-Gly) | Dinucleotideo (nicotinamida + adenina) |
| Classificacao | Peptideo biorregulador sintetico | Coenzima / dinucleotideo |
| Mecanismo Primario | Ativacao da telomerase → elongacao dos telomeros | Ativacao de sirtuinas (SIRT1-7), substrato de PARP, energia celular |
| Alvo no Envelhecimento | Encurtamento dos telomeros (senescencia replicativa) | Declinio de NAD+ (envelhecimento metabolico, disfuncao mitocondrial) |
| Enzima Chave | Telomerase (hTERT) | Sirtuinas, PARPs, CD38 |
| Efeitos Celulares | Desfechos de proliferacao de fibroblastos relatados in vitro | Biogenese mitocondrial, reparo de DNA, regulacao epigenetica |
| Conexao com Melatonina | Restaura a sintese de melatonina pineal em modelos de envelhecimento | Suporta indiretamente o ritmo circadiano via SIRT1/CLOCK |
| Dados de Longevidade | Desfechos de longevidade relatados em modelos de roedores | Reversao do declinio de NAD+ relacionado a idade; dados de tempo de vida mistos |
| Pioneiro da Pesquisa | Prof. Vladimir Khavinson (Instituto de Biorregulacao de Sao Petersburgo) | Prof. David Sinclair (Harvard), Dr. Shin-ichiro Imai (WUSTL) |
Chemical Properties Comparison
| Property | Epithalon | NAD+ |
|---|---|---|
| Molecular Formula | C₁₄H₂₂N₄O₉ | C₂₁H₂₇N₇O₁₄P₂ |
| Molecular Weight | 390.35 Da | 663.43 g/mol |
| CAS Number | 307297-39-8 | 53-84-9 |
| Amino Acid Sequence | — | — |
| PubMed Citations | 0 referenced | 26 referenced |
Explore Full Research Profiles
Epithalon
Visao Geral da Pesquisa Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide geroprotector developed by Prof. Vladimir Khavinson no(a) St. Petersburg Institute of Bioregulacao and Gerontology como o(a) ativo(a) component of Epithalamin (bovine pineal gland extract). Its discovery originated from 1970s Soviet...
NAD+
Visao Geral NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every living cell, serving a dual function como um(a) electron transporter in redox reactions (glycolysis, TCA cycle → ATP production) e um(a) critical substrate for non-redox signaling enzymes incluindo...
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Educational Scope. This comparison summarizes published preclinical and clinical literature for research reference only. It is not medical advice, a recommendation, or guidance for in-human use, and the clinical studies cited were not conducted with the research-grade material supplied by Pure U.S. Peptides. Products are for laboratory research use only.