Semax vs Selank: Comparacao de Pesquisa de Neuropeptideos
Quick Summary
Semax e Selank sao ambos neuropeptideos sinteticos desenvolvidos no Instituto de Genetica Molecular da Academia Russa de Ciencias. Semax e derivado do ACTH(4-7) com uma extensao Pro-Gly-Pro, enquanto Selank e derivado da tuftisina com a mesma cauda estabilizadora Pro-Gly-Pro. Ambos sao registrados como medicamentos na Russia; esse registro nao se aplica ao material de grau de pesquisa. Isso os torna candidatos ideais para analise comparativa de neuropeptideos.
Semax
Visao Geral Semax (ACTH 4-7-PGP) e um(a) sintetico(a) heptapeptide with a sequencia Met-Glu-His-Phe-Pro-Gly-Pro. It was designed by modifying the ACTH(4-7) fragment with a C-terminal Pro-Gly-Pro (PGP) tripeptide para aprimorar enzymatic stability.[2] This modification renders o composto aproximadamente 20 times mais...
Selank
Visao Geral Selank (TP-7) e um(a) sintetico(a) heptapeptide with a sequencia Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It foi desenvolvido(a) por the Institute of Molecular Genetics do(a) Russian Academy of Sciences in cooperation com o(a) V.V. Zakusov Research Institute of Pharmacology.[2] Selank is derivado(a)...
Research Comparison: Semax vs Selank
| Dimension | Semax | Selank |
|---|---|---|
| Molecula de Origem | Fragmento ACTH(4-7) + Pro-Gly-Pro | Tuftisina (Thr-Lys-Pro-Arg) + Pro-Gly-Pro |
| Comprimento de Aminoacidos | 7 aminoacidos (Met-Glu-His-Phe-Pro-Gly-Pro) | 7 aminoacidos (Thr-Lys-Pro-Arg-Pro-Gly-Pro) |
| Mecanismo Primario | Regulacao positiva de BDNF/NGF, modulacao do sistema melanocortina | Modulacao de GABA, inibicao do metabolismo de encefalinas |
| Foco Principal de Pesquisa | Expressao de BDNF e desfechos de lesao neuronal em modelos de roedores | Comportamento do tipo ansioso e marcadores imunes em modelos de roedores |
| Efeitos sobre BDNF | Regulacao positiva significativa (aumento de ate 1,4x no hipocampo) | Modulacao moderada de BDNF, principalmente via sistema serotoninergico |
| Status Regulatorio | Registrado como medicamento na Russia; esse registro nao se aplica ao material de grau de pesquisa | Registrado como medicamento na Russia; esse registro nao se aplica ao material de grau de pesquisa |
| Imunomodulatorio | Leve — foco principalmente neuroprotetor | Forte — derivado da tuftisina, aumenta atividade de celulas NK, modulacao de IL-6 |
| Areas de Pesquisa Unicas | Neuroprotecao retiniana, TDAH, reparo do nervo optico | Modulacao da expressao genica (72+ genes), hepatoprotecao |
| Volume de Pesquisa | 300+ publicacoes (principalmente literatura russa) | 250+ publicacoes (principalmente literatura russa) |
Chemical Properties Comparison
| Property | Semax | Selank |
|---|---|---|
| Molecular Formula | C₃₇H₅₁N₉O₁₀S | C₃₃H₅₇N₁₁O₉ |
| Molecular Weight | 813.93 Da | 751.887 Da |
| CAS Number | 80714-61-0 | 129954-34-3 |
| Amino Acid Sequence | — | — |
| PubMed Citations | 23 referenced | 25 referenced |
Explore Full Research Profiles
Semax
Visao Geral Semax (ACTH 4-7-PGP) e um(a) sintetico(a) heptapeptide with a sequencia Met-Glu-His-Phe-Pro-Gly-Pro. It was designed by modifying the ACTH(4-7) fragment with a C-terminal Pro-Gly-Pro (PGP) tripeptide para aprimorar enzymatic stability.[2] This modification renders o composto aproximadamente 20 times mais...
Selank
Visao Geral Selank (TP-7) e um(a) sintetico(a) heptapeptide with a sequencia Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It foi desenvolvido(a) por the Institute of Molecular Genetics do(a) Russian Academy of Sciences in cooperation com o(a) V.V. Zakusov Research Institute of Pharmacology.[2] Selank is derivado(a)...
More Peptide Comparisons
BPC-157 vs TB-500
Hormonios Liberadores do Hormonio de CrescimentoSermorelin vs Tesamorelin
Hormonios Liberadores do Hormonio de CrescimentoCJC-1295 (com DAC) vs CJC-1295 (sem DAC)
Peptideos RegenerativosGHK-Cu vs BPC-157
Peptideos MetabolicosAOD-9604 vs MOTS-c
Pesquisa de Senescencia CelularEpithalon vs NAD+
For Research Use Only (RUO). This comparison is for educational and informational purposes only. All products are for laboratory research use only. Products have not been approved by the FDA for human or veterinary use. Pure U.S. Peptides does not condone or encourage the use of these products for anything other than strictly defined research applications.
Educational Scope. This comparison summarizes published preclinical and clinical literature for research reference only. It is not medical advice, a recommendation, or guidance for in-human use, and the clinical studies cited were not conducted with the research-grade material supplied by Pure U.S. Peptides. Products are for laboratory research use only.