Sermorelin vs Tesamorelin: Comparacao de Pesquisa de Analogos de GHRH
Quick Summary
Sermorelin e Tesamorelin sao ambos analogos do hormonio liberador do hormonio de crescimento (GHRH) que estimulam a secrecao hipofisaria de GH. Sermorelin corresponde aos primeiros 29 aminoacidos do GHRH(1-44), enquanto Tesamorelin e um GHRH de comprimento total modificado com um grupo de acido trans-3-hexenoico. Tesamorelin e o principio ativo de um medicamento aprovado pela FDA (Egrifta); essa aprovacao nao se aplica ao material de grau de pesquisa, tornando esses dois compostos um par natural para analise comparativa.
Sermorelin
Sermorelin (GHRH 1-29) e um(a) sintetico(a) 29-aminoacido peptide with a peso molecular of 3,357.88 Da. It corresponds para o(a) N-terminal segment do(a) endogenous 44-aminoacido GHRH molecule e e considered the shortest fully functional fragment retaining full biological activity. [1] [2]...
Tesamorelin
Tesamorelin (TH9507) e um(a) sintetico(a) 44-aminoacido analog of endogenous GHRH with a peso molecular of 5135.9 Da. It foi desenvolvido(a) por Theratechnologies Inc. to overcome the inherent instability of native GHRH, que has a meia-vida of apenas 3–8 minutes due...
Research Comparison: Sermorelin vs Tesamorelin
| Dimension | Sermorelin | Tesamorelin |
|---|---|---|
| Estrutura | GHRH(1-29)NH2 — primeiros 29 aminoacidos do GHRH nativo | GHRH(1-44) modificado com acido trans-3-hexenoico — analogo de comprimento total |
| Comprimento de Aminoacidos | 29 aminoacidos | 44 aminoacidos + modificacao com acido hexenoico |
| Mecanismo Primario | Agonismo do receptor GHRH → liberacao hipofisaria de GH | Agonismo do receptor GHRH → pulsatilidade aumentada de GH |
| Status Regulatorio | Aprovado anteriormente (Geref), retirado | Principio ativo de um medicamento aprovado pela FDA (Egrifta); essa aprovacao nao se aplica ao material de grau de pesquisa |
| Meia-vida | ~10-20 minutos (curta) | ~26-38 minutos (mais longa devido a modificacao) |
| Estagio de Pesquisa | Extenso historico clinico; atualmente investigacional | Produto aprovado pela FDA com ensaios de Fase III/IV em andamento |
Chemical Properties Comparison
| Property | Sermorelin | Tesamorelin |
|---|---|---|
| Molecular Formula | C₁₄₉H₂₄₆N₄₄O₄₂S | C₂₂₁H₃₆₆N₇₂O₆₇S |
| Molecular Weight | 3,357.88 Da | 5135.9 Da |
| CAS Number | 86168-78-7 | 218949-48-5 (free base); 901758-09-6 (acetate) |
| Amino Acid Sequence | YADAIFTNSYRKVLGQLSARKLLQDIMSR-NH₂ (29 aa) | hexenoyl-YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH₂ (44 aa) |
| PubMed Citations | 20 referenced | 24 referenced |
Explore Full Research Profiles
Sermorelin
Sermorelin (GHRH 1-29) e um(a) sintetico(a) 29-aminoacido peptide with a peso molecular of 3,357.88 Da. It corresponds para o(a) N-terminal segment do(a) endogenous 44-aminoacido GHRH molecule e e considered the shortest fully functional fragment retaining full biological activity. [1] [2]...
Tesamorelin
Tesamorelin (TH9507) e um(a) sintetico(a) 44-aminoacido analog of endogenous GHRH with a peso molecular of 5135.9 Da. It foi desenvolvido(a) por Theratechnologies Inc. to overcome the inherent instability of native GHRH, que has a meia-vida of apenas 3–8 minutes due...
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For Research Use Only (RUO). This comparison is for educational and informational purposes only. All products are for laboratory research use only. Products have not been approved by the FDA for human or veterinary use. Pure U.S. Peptides does not condone or encourage the use of these products for anything other than strictly defined research applications.
Educational Scope. This comparison summarizes published preclinical and clinical literature for research reference only. It is not medical advice, a recommendation, or guidance for in-human use, and the clinical studies cited were not conducted with the research-grade material supplied by Pure U.S. Peptides. Products are for laboratory research use only.