BPC-157 vs TB-500: Side-by-Side Research Comparison
Quick Summary
BPC-157 and TB-500 are the two most extensively studied tissue-repair peptides in preclinical research. While both demonstrate regenerative properties, they operate through distinct mechanisms — BPC-157 via the FAK-paxillin pathway and NO system, TB-500 via actin sequestration and cell migration. Researchers frequently study these compounds in parallel to understand complementary approaches to tissue recovery.
BPC-157
Overview BPC-157 (Body Protection Compound-157, Bepecin, PL 14736) is a synthetic pentadecapeptide composed of 15 amino acids (GEPPPGKPADDAGLV), derived from a partial sequence of a larger Body Protection Compound protein naturally found in human gastric juice.[1][2] Originally isolated by Dr....
TB-500
Overview TB-500 (also known as Fequesetide) is a synthetic heptapeptide corresponding to the N-acetylated amino acid sequence 17–23 of the naturally occurring protein Thymosin Beta-4 (Tβ4). Its sequence is Ac-LKKTETQ.[1][2] The parent molecule, Thymosin Beta-4, is a ubiquitous 43-amino acid...
Research Comparison: BPC-157 vs TB-500
| Dimension | BPC-157 | TB-500 |
|---|---|---|
| Origin | Gastric juice-derived pentadecapeptide (15 amino acids) | Thymosin beta-4 fragment (43 amino acids) |
| Primary Mechanism | FAK-paxillin pathway activation, NO system modulation, VEGF upregulation | G-actin sequestration, cell migration promotion, anti-inflammatory signaling |
| Primary Research Focus | Gastrointestinal protection, tendon/ligament repair, wound healing | Cardiac tissue repair, dermal wound healing, anti-fibrotic effects |
| Administration Routes Studied | Oral (unique for peptides), IP, topical, IM | Subcutaneous, IP, topical |
| Stability | Highly stable in gastric juice (unique characteristic) | Standard peptide stability; requires reconstitution |
| Key Signaling Pathways | JAK-2/STAT-3, VEGF, eNOS/NO, EGF receptor | Wnt/BMP, Akt/mTOR, NF-kB inhibition |
| Angiogenesis | Promotes via VEGF upregulation | Promotes via endothelial cell migration and tube formation |
| Anti-inflammatory | COX-2 pathway modulation, prostaglandin system | NF-kB inhibition, cytokine downregulation |
| Neuroprotective Effects | Dopaminergic system protection, peripheral nerve repair | Oligodendrocyte differentiation, axonal regrowth |
| Research Stage | Extensive preclinical (800+ publications), limited Phase I/II | Extensive preclinical (1000+ publications), Phase II cardiac trials |
Chemical Properties Comparison
| Property | BPC-157 | TB-500 |
|---|---|---|
| Molecular Formula | C₆₂H₉₈N₁₆O₂₂ | C₃₈H₆₈N₁₀O₁₄ |
| Molecular Weight | 1419.556 g/mol | 889.018 g/mol |
| CAS Number | 137525-51-0 | 885340-08-9 |
| Amino Acid Sequence | — | — |
| PubMed Citations | 30 referenced | 29 referenced |
Explore Full Research Profiles
BPC-157
Overview BPC-157 (Body Protection Compound-157, Bepecin, PL 14736) is a synthetic pentadecapeptide composed of 15 amino acids (GEPPPGKPADDAGLV), derived from a partial sequence of a larger Body Protection Compound protein naturally found in human gastric juice.[1][2] Originally isolated by Dr....
TB-500
Overview TB-500 (also known as Fequesetide) is a synthetic heptapeptide corresponding to the N-acetylated amino acid sequence 17–23 of the naturally occurring protein Thymosin Beta-4 (Tβ4). Its sequence is Ac-LKKTETQ.[1][2] The parent molecule, Thymosin Beta-4, is a ubiquitous 43-amino acid...
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For Research Use Only (RUO). This comparison is for educational and informational purposes only. All products are intended solely for in-vitro research and laboratory experimentation. Products have not been approved by the FDA for human or veterinary use. Pure U.S. Peptides does not condone or encourage the use of these products for anything other than strictly defined research applications.