Melanotan-2: Research Applications
$25.20 · COA do lote publicado · Água BAC grátis + frete grátis nos EUA · Despacho no mesmo dia antes das 14h ET · APENAS PARA USO EM PESQUISA
Comprar peptídeo Melanotan 2 10mg (MT-2)24 Citacoes PubMedRevisado por EspecialistasUltima Revisao: fevereiro de 2026
Aplicacoes de Pesquisa
Melanotan II research spans dermatology, sexual medicine, neuroendocrinology, oncology, and behavioral neuroscience across 7+ indication categories:
- Skin Pigmentation & Photoprotection — MC1R estimulacao → eumelanin synthesis; pigmentation endpoints reported in Phase I trials.[1]
- Sexual Function Research — Erectile-response endpoints reported in small Phase I/II studies; proceptive-behavior endpoints in female rats.[3][9]
- Metabolic Models — Central MC3R/MC4R ativacao in rats: fat-pad mass, iBAT-thermogenesis and food-intake endpoints reported.[6][10]
- Autism & Social Behavior — Sociability index aumentou from 3.1 to 26.3 (p<0.0001) in MIA autism model mice; oxytocin-dependent NAcc ativacao in social contexts; partner preference facilitation in prairie voles.[11][7]
- Neuroprotection & Nerve Regeneration — 20 µg/kg every 48h aprimorou sensory function recovery in rat sciatic nerve crush model.[12]
- Addiction Research — Synergistic augmentation of naltrexone para reduzir binge-like ethanol intake in mice.[13]
- Oncology — Topical MT-II suprimiu melanoma tumor growth via MC1R → PTEN upregulacao + COX-2/PGE2 inibicao; sistemico(a) use carries melanoma risk.[14]
Editorial Research Note
“Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Côté et al.”
Referencias
- Dorr RT, Lines R, Levine N, et al. Life Sciences. 1996;58(20):1777-1784.
- Hadley ME, Dorr RT. Peptides. 2006;27(4):921-930.
- Wessells H, Fuciarelli K, Hansen J, et al. The Journal of Urology. 1998;160(2):389-393.
- FDA Warning Letters regarding unauthorized marketing of Melanotan products.
- Vemulapalli R, Kurowski S, Salisbury B, et al. Activation of central melanocortin receptors by MT-II aumenta cavernosal pressure in rabbits pelo(a) neuronal release of NO. British Journal of Pharmacology. 2001;134(8):1705-1710.
- Côté I, et al. Activation do(a) central melanocortin system chronically reduz body mass sem the necessity of longo prazo caloric restriction. Canadian Journal of Physiology and Pharmacology. 2017.
- Ford CL, McDonough AA, Horie K, Young LJ. Melanocortin agonism in a social context ativa seletivamente nucleus accumbens in an oxytocin-dependent manner. Neuropharmacology. 2024;247:109848.
- Jain S, Panyutin A, Liu N, et al. Melanotan II causes hypothermia in mice by ativacao of mast cells and estimulacao of histamine 1 receptors. American Journal of Physiology-Endocrinology and Metabolism. 2018;315(3):E357-E366.
- Wessells H, Levine N, Hadley ME, Dorr RT, Hruby VJ. Urology. 2000;56(4):641-646.
- Eliason NL, Martin L, Low MJ, Sharpe AL. Melanocortin agonista do receptor melanotan-II microinjected no(a) nucleus accumbens diminui appetitive and consumptive responding for food. Neuropeptides. 2022;96:102289.
- Minakova E, Lang J, Medel-Matus JS, et al. PLoS ONE. 2019;14(1):e0210389.
- Ter Laak MP, et al. Melanotan II promove periferico(a) regeneracao nervosa in a rat sciatic nerve crush model. 2003.
- Evans-Brown M, Dawson RT, Chandler MD, McVeigh J. Use of melanotan I and II no(a) general population. BMJ. 2009;338:b566.
- Wu JC, Tsai HE, Hsiao YH, et al. International Journal of Molecular Sciences. 2020;21(2):681.
- Dreyer BA, Amer T, Fraser M. BMJ Case Reports. 2019;12(2):e227644.
- Nelson ME, Bryant SM, Aks SE. Clinical Toxicology. 2012;50(10):1169-1173.
- Peters B, Hadimeri H, Wahlberg R, Afghahi H. CEN Case Reports. 2020;9(2):159-161.
- Sivyer GW. Dermatology Practical & Conceptual. 2012.
- Ryakhovsky VV, Khachiyan GA, Kosovova NF, et al. The primeiro(a) preparative solution phase synthesis of melanotan II. Beilstein Journal of Organic Chemistry. 2008;4:39.
- Hjuler KF, Lorentzen HF. Melanoma associado(a) com the use of melanotan-II. Dermatology. 2014;228(1):34-36.
- Giuliano F, Clement P, Droupy S, et al. Neuroscience. 2006;138(1):293-301.
- Li G, Zhang Y, Wilsey JT, Scarpace PJ. Unabated anorexic and aprimorou thermogenic responses to melanotan II in diet-induziu ratos obesos. Journal of Endocrinology. 2004;182(1):123-132.
- King SH, et al. Current Topics in Medicinal Chemistry. 2007;7(11):1111-1119.
- Wessells H, Levine N, Hadley ME, Dorr RT, Hruby VJ. International Journal of Impotence Research. 2000;12(Suppl 4):S74-S79.
Perguntas de Pesquisa Relacionadas
Related research
Browse all research guides in the Peptide Research Library →Deseja a revisao completa da pesquisa?
Comprar peptídeo Melanotan 2 10mg (MT-2)→APENAS PARA USO EM PESQUISA
Este conteudo e fornecido apenas para fins educacionais e informativos. Os produtos sao fornecidos apenas para estudos in vitro e nao sao medicamentos, drogas ou suplementos. Nao aprovado pela FDA para prevenir, tratar ou curar qualquer condicao.