Visao Geral Kisspeptin refers to a family of neuropeptides derivado(a) de the KISS1 gene, originally descoberto(a) em 1996 by Danny R. Welch and J.H. Lee in Hershey, Pennsylvania, como um(a) melanoma metastasis suppressor. The gene was named "KiSS-1" to honor the discovery location near the Hershey's Kisses chocolate factory, with "SS" denoting "suppressor sequence."[1] The KISS1 gene encodes a 145-aminoacido prepro-kisspeptin precursor que undergoes proteolytic cleavage to produce four biologic

How does Kisspeptin work? What is its mechanism of action?

Mecanismo de Acao KISS1R (GPR54) Receptor Binding Kisspeptin acts by binding KISS1R (GPR54/AXOR12), a rhodopsin-like Class A GPCR sharing ~45% identity with galanin receptors (but nao bind galanin). The essencial pharmacophore e o(a) C-terminal RF-amide motif; key residues Phe-6 and Arg-9 (Kp-10 numbering) are critico(a) para binding. Cryo-EM studies reveal an orthosteric pocket spanning TM2–7 plus ECL1–3.[2][3] Primary Gαq/11–PLC–Ca²⁺ Pathway KISS1R couples primariamente to Gαq/11, activating p

What are the research applications of Kisspeptin?

Aplicacoes de Pesquisa Kisspeptin is one do(a) a maioria extensively studied reproductive neuropeptides, with >1,000 human subjects across Phase 1/2 ensaios clinicos: IVF Oocyte Maturation Trigger — Kp-54 has been studied as an oocyte-maturation trigger in IVF cohorts; oocyte-maturation, live-birth and OHSS endpoints are reported in the cited references.[10][11] Hypothalamic Amenorrhea — LH-pulsatility endpoints reported over an 8-week study.[12][13][19] PCOS — LH and estradiol endpoints were re

What does the research summary say about Kisspeptin?

Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Mills et al. (2025)C57BL/6J mice — Kp-5412.8–50 nM: dose-dependente LH to 3.6 ng/mL at 25 min (p [19] Izarraras et al. (2025)DIAMOND mice — TAK-448 MASLD0.3 nmol/h × 6 weeks: reduziu liver triglycerides, serum FFA, ALT (p [18] Seminara/Ramaswamy (2006/07)Juvenile rhesus monkeys — IV KP-10200–400 µg/h × 98h: maximal LH at 3h, dessensibilizacao by 12h; GnRH bolus still eficaz but KP-10 bolus was not[23] Terse

How should Kisspeptin be stored?

Armazene liofilizado kisspeptin a −20°C. Evite congelamento-descongelamento repetido.

Kisspeptin Research Applications — Scientific Studies & Evidence

Aplicacoes de Pesquisa

Kisspeptin is one do(a) a maioria extensively studied reproductive neuropeptides, with >1,000 human subjects across Phase 1/2 ensaios clinicos:

IVF Oocyte Maturation Trigger — Kp-54 has been studied as an oocyte-maturation trigger in IVF cohorts; oocyte-maturation, live-birth and OHSS endpoints are reported in the cited references.[10][11]
Hypothalamic Amenorrhea — LH-pulsatility endpoints reported over an 8-week study.[12][13][19]
PCOS — LH and estradiol endpoints were reported with KP-10 in women with polycystic ovary syndrome.[15]
Metabolic / Fatty Liver Disease — TAK-448 reduz hepatico(a) triglycerides, serum FFA, and ALT in MASLD models via AMPK→SREBP-1c→CIDEA downregulacao.[18]
Cancer Metastasis Suppression — Originally identificado(a) como melanoma/breast cancer metastasis suppressor ("metastin"); inibe MMP-9 via NF-κB pathway supressao.[1]
Prostate Cancer (Androgen Deprivation) — Continuous TAK-448/MVT-602 exposure → receptor dessensibilizacao → testosterone supressao to castrate levels (Phase 1 data).[14]
Pregnancy Biomarker — Kisspeptin rises 7,000-fold during healthy pregnancy; baixo(a) levels predict miscarriage/preeclampsia by assessing trophoblast invasion.[20]
Bone Health — Promotes osteoblasto diferenciacao, inibe osteoclasto activity; osteocalcin endpoints have been reported in men.[21]
Puberty Disorders — Activating/inactivating KISS1/KISS1R mutations linked to precocious/retardou puberty; kisspeptin challenge tests used diagnostically.[4]
Metabolic Insulin Signaling — glucose-stimulated insulin-secretion endpoints have been reported in healthy men.[22]

Aplicacoes de Pesquisa

Kisspeptin is one do(a) a maioria extensively studied reproductive neuropeptides, with >1,000 human subjects across Phase 1/2 ensaios clinicos:

IVF Oocyte Maturation Trigger — Kp-54 has been studied as an oocyte-maturation trigger in IVF cohorts; oocyte-maturation, live-birth and OHSS endpoints are reported in the cited references.[10][11]
Hypothalamic Amenorrhea — LH-pulsatility endpoints reported over an 8-week study.[12][13][19]
PCOS — LH and estradiol endpoints were reported with KP-10 in women with polycystic ovary syndrome.[15]
Metabolic / Fatty Liver Disease — TAK-448 reduz hepatico(a) triglycerides, serum FFA, and ALT in MASLD models via AMPK→SREBP-1c→CIDEA downregulacao.[18]
Cancer Metastasis Suppression — Originally identificado(a) como melanoma/breast cancer metastasis suppressor ("metastin"); inibe MMP-9 via NF-κB pathway supressao.[1]
Prostate Cancer (Androgen Deprivation) — Continuous TAK-448/MVT-602 exposure → receptor dessensibilizacao → testosterone supressao to castrate levels (Phase 1 data).[14]
Pregnancy Biomarker — Kisspeptin rises 7,000-fold during healthy pregnancy; baixo(a) levels predict miscarriage/preeclampsia by assessing trophoblast invasion.[20]
Bone Health — Promotes osteoblasto diferenciacao, inibe osteoclasto activity; osteocalcin endpoints have been reported in men.[21]
Puberty Disorders — Activating/inactivating KISS1/KISS1R mutations linked to precocious/retardou puberty; kisspeptin challenge tests used diagnostically.[4]
Metabolic Insulin Signaling — glucose-stimulated insulin-secretion endpoints have been reported in healthy men.[22]

Kisspeptin: Research Applications

Aplicacoes de Pesquisa

Referencias

Perguntas de Pesquisa Relacionadas

Related research

Kisspeptin: Research Applications

Aplicacoes de Pesquisa

Referencias

Perguntas de Pesquisa Relacionadas

Related research