Visao Geral Melanotan II (MT-II) e um(a) sintetico(a), cyclic heptapeptide analog do(a) endogenous 13-amino-acid hormone α-melanocyte-stimulating hormone (α-MSH). It was originally synthesized no(a) University of Arizona no(a) late 1980s by Victor Hruby, Mac Hadley, and Robert Dorr.[1] Chemically, MT-II is defined as Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂, a shortened variant of α-MSH with key modifications: a lactam bridge cyclization (Asp→Lys) aumenta enzymatic resistance, and D-Phenylalanine

How does Melanotan-2 work? What is its mechanism of action?

Mecanismo de Acao Melanocortin Receptor Binding MT-II is a non-selective agonist at four of five melanocortin receptors (MCRs), all members do(a) GPCR superfamily: ReceptorPrimary LocationFunction When ActivatedAffinity MC1RMelanocytes (skin)Eumelanin synthesis → tanning/photoprotectionHigh MC3RHypothalamus, NAccEnergy homeostasis, feeding behaviorKi ~1.3 nM MC4RHypothalamus (PVN), spinal cordErectile function, appetite supressao, thermogenesisKi ~1.1 nM MC5RExocrine glands, linfocitosSebum prod

What are the research applications of Melanotan-2?

Aplicacoes de Pesquisa Melanotan II research spans dermatology, sexual medicine, neuroendocrinology, oncology, and behavioral neuroscience across 7+ indication categories: Skin Pigmentation & Photoprotection — MC1R estimulacao → eumelanin synthesis; pigmentation endpoints reported in Phase I trials.[1] Sexual Function Research — Erectile-response endpoints reported in small Phase I/II studies; proceptive-behavior endpoints in female rats.[3][9] Metabolic Models — Central MC3R/MC4R ativacao in ra

What does the research summary say about Melanotan-2?

Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Côté et al. (2017)F344BN rats — 40-day studyFat pads -35% to -55% (p3-fold ↑; food intake returned to normal by day 5 — body-weight endpoint via ↑ energy expenditure[6] Vemulapalli et al. (2001)NZW rabbits — 66–133 µg/kg IVCavernosal pressure 3.2-fold ↑ (p[5] Minakova et al. (2019)MIA autism-model mice — 7-day studySociability index 3.1 → 26.3 (p[11] Ford et al. (2024)Prairie voles (WT vs Oxtr-KO) — IP/ICVSo

How should Melanotan-2 be stored?

Pó liofilizado: -20°C, escuro, hermético, protegido de moisture. Evite congelamento-descongelamento repetido.

Melanotan-2: Chemical Properties

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Comprar peptídeo Melanotan 2 10mg (MT-2)

24 Citacoes PubMedRevisado por EspecialistasUltima Revisao: fevereiro de 2026

Propriedades Quimicas

Molecular Formula	C₅₀H₆₉N₁₅O₉
Molecular Weight	1024.18 Da
CAS Number	121062-08-6
PubChem CID	92432
Sequence	Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Structure	Cyclic heptapeptide; lactam bridge (Asp-Lys); Ac-Nle replaces α-MSH Ser-Tyr-Ser-Met; D-Phe replaces L-Phe
Parent Molecule	α-MSH (alpha-melanocyte-stimulating hormone)
InChI Key	JDKLPDJLXHXHNV-MFVUMRCOSA-N
Half-Life (Human)	~1–2 hours (aprimorou vs α-MSH by cyclic structure)
BBB Penetration	Yes (diferentemente de Melanotan I)
Receptor Profile	Non-selective MCR agonist: MC1R, MC3R (Ki 1.3 nM), MC4R (Ki 1.1 nM), MC5R; NO activity at MC2R

Identificadores

Purity Standard	≥98% by RP-HPLC
Identity Confirmation	ESI-MS m/z 512 [M+2H]²⁺ and 1024 [M+H]⁺; LC-UV-MS/MS validated
Counter-Ion	Não informado no certificado de lote publicado
Synonyms	MT-II, MT2, Melanotan-II, Barbie drug/peptide
Detection Methods	HPLC, ESI-MS, LC-UV-MS/MS, urine/blood MS (toxicology)

Editorial Research Note

“Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Côté et al.”

Pure U.S. Peptides Research Standards TeamInternal editorial group summarising published peptide research for an audience of qualified independent investigators.

Referencias

Perguntas de Pesquisa Relacionadas

→ What Is Melanotan-2?→ Melanotan-2: Mechanism of Action → Melanotan-2: Research Applications → Melanotan-2: Safety Profile & Research Summary → Storing Melanotan-2: Best Practices

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Este conteudo e fornecido apenas para fins educacionais e informativos. Os produtos sao fornecidos apenas para estudos in vitro e nao sao medicamentos, drogas ou suplementos. Nao aprovado pela FDA para prevenir, tratar ou curar qualquer condicao.