Visao Geral LL-37 is a 37-residue cationic antimicrobial peptide (AMP) e o(a) only member do(a) cathelicidin family identificado(a) in humans. Its aminoacido sequence is LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES.[1] Parent molecule: LL-37 is derivado(a) de a larger, inactive precursor protein called hCAP18 (human Cationic Antimicrobial Protein, 18 kDa). The CAMP gene on chromosome 3p21.3 encodes hCAP18. The ativo(a) LL-37 peptide is released extracellularly through proteolytic cleavage — primariamen

How does LL-37 work? What is its mechanism of action?

Mecanismo de Acao Primary Antimicrobial: "Carpet-Like" Membrane Disruption LL-37 disrupts bacterial membranes via electrostatic attraction to anionic bacterial surfaces → hydrophobic insertion → toroidal pore formation or micellization ("carpet-like" mechanism). It acts preferentially on Gram-negative bacteria but is eficaz against ambos(as) Gram-positive and drug-resistant strains. Eukaryotic membranes are protegeu by alto(a) cholesterol content.[3][7] Receptor Targets ReceptorTypeFunctional Ef

What are the research applications of LL-37?

Aplicacoes de Pesquisa LL-37 research spans antimicrobial resistance, cicatrizacao de feridas, oncology, and immunology across 8+ indication categories: Chronic Wound Healing — Promotes granulation tissue, re-epitelialization, and angiogenese in venous leg ulcers (VLUs) and diabetic foot ulcers (DFUs).[5][13] Antimicrobial Resistance — Broad-spectrum activity against MDR bacteria; anti-biofilm; synergy with conventional antibiotics (azithromycin, colistin, ciprofloxacin, vancomycin).[7] Oncology

What does the research summary say about LL-37?

Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Zhang et al. (2022)C57/BL6 mice, Pan02 PDAC — 20 mg/kg/day × 14d42% reduction in tumor growth (p[11] Overhage et al. (2008)P. aeruginosa biofilm — 0.5 µg/mLInhibits biofilm formation via quorum-sensing downregulacao (Las/Rhl); promove twitching motility at sub-MIC[7] Wu et al. (2010)Colon cancer cellsLL-37 inibe proteasome → ativa BMP signaling → p21Waf1 → cell cycle arrest[10] Koczulla et al. (2003)Dexameth

How should LL-37 be stored?

Pó liofilizado/concentrado armazenado a -20°C.

LL-37: Chemical Properties

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Comprar peptídeo LL-37 5mg (Cathelicidin)

24 Citacoes PubMedRevisado por EspecialistasUltima Revisao: fevereiro de 2026

Propriedades Quimicas

Molecular Formula	C₂₀₅H₃₄₀N₆₀O₅₃
Molecular Weight	4493.33 Da
CAS Number	Not estabeleceu
PubChem CID	16198951
Sequence (1-Letter)	LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Sequence (3-Letter)	Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
Structure	Linear, amphipathic α-helix (in membranes), cysteine-free, curved helix-bend-helix motif (residues 2–31)
Net Charge	+6 at physiological pH
Gene Origin	CAMP gene, chromosome 3p21.3 — encodes hCAP18 precursor
Classification	Cathelicidin Antimicrobial Peptide / Host Defense Peptide
Clinical Name	Ropocamptide (Promore Pharma AB)

Identificadores

Purity Standard	≥90–110% content by HPLC (UV at 217 nm)
Identity Confirmation	LC-MS molecular mass ~4493.33 Da
Counter-Ion	Acetate (synthetic peptide acetate salt via SPPS)
Detection Methods	RP-HPLC, LC-MS, aminoacido analysis, ELISA, antimicrobial bioassays

Editorial Research Note

“Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Zhang et al.”

Pure U.S. Peptides Research Standards TeamInternal editorial group summarising published peptide research for an audience of qualified independent investigators.

Referencias

Perguntas de Pesquisa Relacionadas

→ What Is LL-37?→ LL-37: Mechanism of Action → LL-37: Research Applications → LL-37: Safety Profile & Research Summary → Storing LL-37: Best Practices

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Este conteudo e fornecido apenas para fins educacionais e informativos. Os produtos sao fornecidos apenas para estudos in vitro e nao sao medicamentos, drogas ou suplementos. Nao aprovado pela FDA para prevenir, tratar ou curar qualquer condicao.