Visao Geral GHK-Cu (Copper Tripeptide-1) e um(a) que ocorre naturalmente tripeptide complex consistindo de the aminoacidos Glycyl-L-Histidyl-L-Lysine chelated to a copper(II) ion. First isolado(a) from human plasma albumin in 1973 by Dr. Loren Pickart at UCSF.[1] Origin: GHK e um(a) endogeno(a) peptide encontrado(a) em human plasma, saliva, and urine. It is liberado(a) de the matriz extracelular during tissue injury — specifically cleaved from SPARC (Secreted Protein Acidic and Rich in Cysteine)

How does GHK-Cu work? What is its mechanism of action?

Mecanismo de Acao Copper Transport & "Redox Silencing" GHK-Cu acts como um(a) carrier peptide with alto(a) affinity for copper(II) ions (pKa = 16.44). The complex "silences" copper's redox activity, preventing Fenton reaction damage enquanto delivering copper safely into cells — essencial para enzymes like lysyl oxidase (collagen crosslinking) and superoxide dismutase (antioxidante defense).[3] Key Signaling Pathways PathwayMecanismoEffect NF-κB/p38 MAPKInhibits fosforilacao of NF-κB p65 and p38

What are the research applications of GHK-Cu?

Aplicacoes de Pesquisa GHK-Cu research spans dermatology, cicatrizacao de feridas, pulmonology, oncology, and neuroscience across 10+ indication categories: Wound Healing & Tissue Regeneration — Accelerates contraction, re-epitelialization, collagen accumulation; reduz TNF-α and MMPs. 64.5% wound size reduction vs 28.2% control (Canapp et al., 2003).[11] Dermatology Research — Skin-elasticity, density and collagen-production endpoints reported in cosmetic studies (collagen production 70% vs 50%

What does the research summary say about GHK-Cu?

Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Canapp et al. (2003)Rats — ischemic open wounds, topico(a) daily × 13dWound size ↓ 64.5% vs 28.2% control; ↓ TNF-α, MMP-2, MMP-9[11] Maquart et al. (1993)Sprague-Dawley rats — wound chambersDose-dependent ↑ Collagen I/III, GAGs, DNA content (days 3–14)[10] Zhang et al. (2022)C57BL/6J mice — CS-induziu emphysema, 12-week studySignificantly ↓ airspace enlargement; reversed MMP-9/TIMP-1 imbalance; Nrf2/Keap1 at

How should GHK-Cu be stored?

Lyophilized pó a -20°C (até 3 anos). Estável pH 5.0–7.0; dissocia abaixo de pH 4 ou acima de pH 9. Mantenha longe de umidade sob gás inerte.

GHK-Cu: Chemical Properties

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24 Citacoes PubMedRevisado por EspecialistasUltima Revisao: fevereiro de 2026

Propriedades Quimicas

Molecular Formula	C₁₄H₂₂CuN₆O₄
Molecular Weight	~401.9 Da
CAS Number	89030-95-5
PubChem CID	378611
Sequence (1-Letter)	GHK
Sequence (3-Letter)	Gly-His-Lys
Structure	Linear tripeptide chelated to Cu(II) in distorted square-planar pyramid; blue-purple crystal powder
InChI Key	DIWZQABMLHSNJR-UHFFFAOYSA-N
SMILES	C1=C(NC=N1)CC(C(=O)NC(CCCCN)C(=O)O)NC(=O)CN.[Cu]
Origin	Endogenous — human plasma, cleaved from SPARC and type I collagen α2 chain
Classification	Copper Peptide Complex / Cosmeceutical / Research Peptide
Appearance	Blue-purple crystal powder (GHK sem copper is white)

Identificadores

Purity Standard	Certificado de lote pendente
Identity Confirmation	Certificado de lote pendente
Counter-Ion	Não informado no certificado de lote publicado
Detection Methods	RP-HPLC, Mass Spectrometry, Atomic Absorption, ICP-MS for copper

Editorial Research Note

“Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Canapp et al.”

Pure U.S. Peptides Research Standards TeamInternal editorial group summarising published peptide research for an audience of qualified independent investigators.

Referencias

Perguntas de Pesquisa Relacionadas

→ What Is GHK-Cu?→ GHK-Cu: Mechanism of Action → GHK-Cu: Research Applications → GHK-Cu: Safety Profile & Research Summary → Storing GHK-Cu: Best Practices

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Este conteudo e fornecido apenas para fins educacionais e informativos. Os produtos sao fornecidos apenas para estudos in vitro e nao sao medicamentos, drogas ou suplementos. Nao aprovado pela FDA para prevenir, tratar ou curar qualquer condicao.