What Is Epithalon?
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Research Overview Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide geroprotector developed by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology as the active component of Epithalamin (bovine pineal gland extract). Its discovery originated from 1970s Sov...
Research Overview
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide geroprotector developed by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology as the active component of Epithalamin (bovine pineal gland extract). Its discovery originated from 1970s Soviet military research to protect soldiers from radiation and accelerated aging.[4]
Epithalon's mechanism is fundamentally different from classical receptor-ligand pharmacology. Rather than binding a cell surface receptor, it enters the nucleus and interacts directly with DNA (targeting CAG repeats and ATTTC promoter sequences) and histone proteins (H1.3, H1.6) — functioning as an epigenetic switch that converts heterochromatin to euchromatin, making silenced genes accessible for transcription.[1][3]
Research spans 10+ indication categories across gerontology, oncology, ophthalmology, endocrinology, and neuroscience — with over 50 years of study (1970s–2025). The "Epithalon Paradox" — activating telomerase while simultaneously inhibiting cancer — challenges conventional oncological assumptions and remains a major focus of current research.[7]
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