Epithalon: Research Applications

Research Applications

Epithalon research spans 10+ indication categories with over 50 years of investigation (1970s–2025):

1. Telomere Extension & Cellular Senescence — Cells surpass Hayflick limit; telomere elongation confirmed in patients aged 60–80 (9.61→10.72 kb and 7.51→8.91 kb, p<0.05).[5]
2. Cancer Prevention Paradox — Inhibits spontaneous tumors in HER-2/neu mice; reduces oncogene expression 3.7-fold; anti-metastatic — despite telomerase activation.[7][14]
3. Retinal Degeneration / Retinitis Pigmentosa — 90% positive clinical effect in 162 patients; visual field expanded 90–120°.[9]
4. Circadian Rhythm & Sleep Regulation — Restores youthful melatonin secretion; normalizes cortisol rhythms in aged monkeys and humans.[11][15]
5. Neuroprotection & Neurogenesis — Upregulates Nestin, GAP43, Beta-Tubulin III in stem cells; promotes neuronal differentiation.[3]
6. Immune System Rejuvenation — ↑ IL-2, T-cell proliferation; corrects age-related CD4+/CD8+ ratios.[4]
7. Antioxidant Defense — ↑ SOD (+41%), catalase (+20%), glutathione peroxidase; ↓ lipid peroxidation and ROS.[6]
8. Diabetic Retinopathy / Wound Healing — Inhibits EMT and fibrosis in high-glucose RPE cells.[12]
9. Reproductive Health — Restores estrous cycles in aged rats; improves oocyte quality and blastocyst hatching.[10]
10. Geroprotection / Anti-Aging — Maximum lifespan increased 12–13% in mice; up to 24% in CBA model; reduced chromosomal aberrations.[7][8]