KLOW: Chemical Properties
14 PubMed CitationsExpert ReviewedLast Reviewed: April 2026
Chemical Properties
| Composition | 50 mg GHK-Cu + 10 mg BPC-157 + 10 mg TB-500 + 10 mg KPV |
| Total Mass Per Vial | 80 mg lyophilized blend |
| GHK-Cu Component | Glycyl-L-Histidyl-L-Lysine-Cu(II); MW ~401.9 Da |
| BPC-157 Component | GEPPPGKPADDAGLV; MW 1419.556 g/mol |
| TB-500 Component | Ac-LKKTETQ; MW 889.018 g/mol |
| KPV Component | Lys-Pro-Val (Ξ±-MSH 11β13); MW 342.4 Da; CAS 67727-97-3 |
| Appearance | White-to-pale-blue lyophilized powder |
| Classification | Multi-component research peptide blend |
Identifiers
| Purity Standard | Lot certificate pending |
| Identity Confirmation | Lot certificate pending |
| Counter-Ion | Not reported on the published lot certificate |
| Detection Methods | RP-HPLC, LC-MS/MS, ICP-MS for GHK-Cu copper content |
Editorial Research Note
βPreclinical Research Summary (Component-Level) No peer-reviewed studies have evaluated the KLOW 50/10/10/10 blend as a co-administered formulation.β
References
- Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide. International Journal of Molecular Sciences. 2018;19(7):1987.
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways. BioMed Research International. 2015;2015:648108.
- Sikiric P, et al. Current Pharmaceutical Design. 2011;17(16):1612-1632.
- Dalmasso G, et al. PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation. Gastroenterology. 2008;134(1):166-178.
- U.S. Food and Drug Administration. Certain Bulk Drug Substances for Use in Compounding. FDA.gov. Updated 2023.
- Hsieh MJ, et al. Journal of Molecular Medicine. 2017;95(3):323-333.
- Goldstein AL, et al. Thymosin Ξ²4: a multi-functional regenerative peptide. Expert Opinion on Biological Therapy. 2012;12(1):37-51.
- Philp D, Goldstein AL, Kleinman HK. Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development. Mechanisms of Ageing and Development. 2004;125(2):113-115.
- Brzoska T, Luger TA, Maaser C, et al. Endocrine Reviews. 2008;29(5):581-602.
- Park JR, et al. The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury. Oncotarget. 2016;7(36):58405-58417.
- Sikiric P, et al. Brain-gut axis and pentadecapeptide BPC 157. Current Neuropharmacology. 2016;14(8):857-865.
- Rahaman KA, Muresan AR, Min H, et al. Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro. Journal of Chromatography B. 2024;1235:124033.
- Kannengiesser K, et al. KPV has anti-inflammatory potential in murine IBD models. Inflammatory Bowel Diseases. 2008;14(3):324-331.
- Xiao B, et al. Molecular Therapy. 2017;25(7):1628-1640.
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This content is provided for educational and informational purposes only. Products are furnished for in-vitro studies only and are not medicines, drugs, or supplements. Not approved by the FDA to prevent, treat, or cure any condition.