Kisspeptin: Chemical Properties
$34.65 · COA de lote publicado · Agua BAC gratis + envío gratis en EE. UU. · Despacho el mismo día antes de las 2 PM ET · SOLO PARA USO EN INVESTIGACIÓN
Comprar péptido Kisspeptin 10mg30 Citas PubMedRevisado por EspecialistasÚltima Revisión: febrero de 2026
Propiedades Químicas
| Gene | KISS1 (chromosome 1q32, human) |
| Precursor Size | 145 amino acids (prepro-kisspeptin) |
| Molecular Weight (Kp-54) | ~5.9 kDa |
| Molecular Weight (Kp-10) | ~1.3 kDa |
| Sequence (Kp-10, Human) | YNWNSFGLRF-NH₂ (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂) |
| Sequence (Kp-10, Rodent) | YNWNSFGLRY-NH₂ |
| C-Terminal Motif | RF-amide (Arg-Phe-NH₂) — critical for KISS1R binding |
| Receptor | KISS1R (GPR54/AXOR12) — Class A rhodopsin-like GPCR |
| Isoforms | Kp-54, Kp-14, Kp-13, Kp-10 (all share C-terminal decapeptide) |
| Synonyms | Metastin, KiSS-1-derived peptide, Kp-54, Kp-14, Kp-13, Kp-10 |
| Analogs | MVT-602 (TAK-448), TAK-683 |
| Plasma Half-Life | Kp-10 ~4 min; Kp-54 ~27.6 min; MVT-602 peaks at 21h |
Identificadores
| Purity Standard | ≥97% by RP-HPLC |
| Identity Confirmation | No informado en el certificado de lote publicado |
| Endotoxin | Negative by LAL assay |
| Sterility | No informado en el certificado de lote publicado |
Editorial Research Note
“Resumen de Investigación Preclínica Estudios Preclínicos Clave EstudioModeloHallazgos ClaveRef Mills et al.”
Referencias
- Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, Welch DR. Journal of the National Cancer Institute. 1996;88(23):1731-1737.
- Ohtaki T, Shintani Y, Honda S, et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. 2001;411(6837):613-617.
- Kotani M, Detheux M, Vandenbogaerde A, et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. Journal of Biological Chemistry. 2001;276(37):34631-34636.
- Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 gene as a regulator of puberty. New England Journal of Medicine. 2003;349(17):1614-1627.
- Dhillo WS, Chaudhri OB, Patterson M, et al. Journal of Clinical Endocrinology & Metabolism. 2005;90(12):6609-6615.
- Dhillo WS, Chaudhri OB, Thompson EL, et al. Journal of Clinical Endocrinology & Metabolism. 2007;92(10):3958-3966.
- World Anti-Doping Agency. The Prohibited List. S2 Peptide Hormones, Growth Factors, Related Substances, and Mimetics. WADA. Updated 2025.
- de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E. Proceedings of the National Academy of Sciences. 2003;100(19):10972-10976.
- Abbara A, Eng PC, Phylactou M, et al. Journal of Clinical Investigation. 2020;130(12):6739-6753.
- Abbara A, Jayasena CN, Christopoulos G, et al. Journal of Clinical Endocrinology & Metabolism. 2015;100(9):3322-3331.
- Abbara A, Clarke S, Islam R, et al. Human Reproduction. 2017;32(9):1915-1924.
- Jayasena CN, Nijher GM, Chaudhri OB, et al. Journal of Clinical Endocrinology & Metabolism. 2009;94(11):4315-4323.
- Jayasena CN, Nijher GM, Abbara A, et al. Clinical Pharmacology & Therapeutics. 2010;88(6):840-847.
- MacLean DB, Matsui H, Suri A, Neuwirth R, Colombel M. Journal of Clinical Endocrinology & Metabolism. 2014;99(8):E1445-E1453.
- Skorupskaite K, et al. Human Reproduction. 2020.
- Comninos AN, Wall MB, Demetriou L, et al. Journal of Clinical Investigation. 2017;127(2):709-719.
- Mills EG, et al. JAMA Network Open. 2023.
- Izarraras L, et al. Kisspeptin agonist reduces hepatic de novo lipogenesis in MASLD via AMPK-SREBP-1c-CIDEA. 2025.
- Mills EG, et al. eBioMedicine. 2025.
- Jayasena CN, Abbara A, et al. Journal of Clinical Investigation. 2014;124(8):3667-3677.
- Comninos AN, et al. Journal of Clinical Endocrinology & Metabolism. 2022.
- Izzi-Engbeaya C, et al. Diabetes, Obesity and Metabolism. 2018.
- Seminara SB, et al. 2006.
- Terse PS, et al. 2021.
- Thompson EL, et al. 2006.
- Dinh TO, et al. Kisspeptin-13 exacerbates chronic kidney disease and uremic cardiomyopathy in rats. 2023.
- George JT, Veldhuis JD, Roseweir AK, et al. Journal of Clinical Endocrinology & Metabolism. 2011;96(8):E1228-E1236.
- Thurston L, et al. JAMA Network Open. 2022.
- Nishizawa N, Takatsu Y, et al. Design and synthesis of TAK-448, an investigational nonapeptide KISS1R agonist. Journal of Medicinal Chemistry. 2016;59(19):8804-8811.
- Chan YM, Butler JP, Pinnell NE, et al. Journal of Clinical Endocrinology & Metabolism. 2011;96(6):E908-E915.
Preguntas de Investigación Relacionadas
Related research
Browse all research guides in the Peptide Research Library →Desea la revisión completa de la investigación?
Comprar péptido Kisspeptin 10mg→SOLO PARA USO EN INVESTIGACIÓN
Este contenido se proporciona solo para fines educativos e informativos. Los productos se suministran exclusivamente para estudios in vitro y no son medicamentos, fármacos ni suplementos. No están aprobados por la FDA para prevenir, tratar o curar ninguna condición.