GLOW: Safety Profile & Research Summary
Preclinical Research Summary (Component-Level)
No peer-reviewed studies have evaluated the GLOW 50/10/10 blend as a co-administered formulation. The studies below summarize key findings for each individual component. For full per-component data tables and clinical references, see the dedicated GHK-Cu, BPC-157, and TB-500 entries.
Component-Level Highlights
| Component | Representative Study | Key Finding |
|---|---|---|
| GHK-Cu | Canapp et al. (2003) — rat ischemic wounds | Wound size ↓ 64.5% vs 28.2% control; ↓ TNF-α, MMP-2/9 |
| GHK-Cu | Pickart & Margolina (2018) — gene-data review | Modulates >4,000 genes (gene-expression data review) |
| BPC-157 | Hsieh et al. (2017) — rat hind-limb ischemia + CAM | 129–152% increased angiogenesis; VEGFR2-Akt-eNOS confirmed |
| BPC-157 | Staresinic et al. (2003) — rat Achilles transection | 10 µg/kg: improved AFI scores and load-to-failure 14–72d |
| TB-500 | Philp et al. (2003) — db/db diabetic and aged mice | LKKTETQ fragment promoted dermal repair comparable to full Tβ4 |
| TB-500 (parent Tβ4) | Bock-Marquette et al. (2004) — Nature | Tβ4 activates ILK → cardiac cell migration, survival, repair |
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
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“Preclinical Research Summary (Component-Level) No peer-reviewed studies have evaluated the GLOW 50/10/10 blend as a co-administered formulation.”
Referencias
- Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences. 2018;19(7):1987.
- Sikiric P, Hahm KB, Blagaic AB, Tvrdeic A, et al. Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye's Stress Coping Response: Progress, Achievements, and the Future. Gut and Liver. 2020;14(2):153-167.
- Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: a multi-functional regenerative peptide. Expert Opinion on Biological Therapy. 2012;12(1):37-51.
- Pickart L, Vasquez-Soltero JM, Margolina A. Cosmetics. 2015;2(3):236-247.
- Hsieh MJ, et al. Journal of Molecular Medicine. 2017;95(3):323-333.
- Xing Y, Ye Y, Zuo H, Li Y. Progress on the Function and Application of Thymosin β4. Frontiers in Endocrinology. 2021;12:767785.
- U.S. Food and Drug Administration. Certain Bulk Drug Substances for Use in Compounding. FDA.gov. Updated 2023.
- World Anti-Doping Agency. The 2025 Prohibited List. WADA. January 1, 2025.
- Pickart L, Vasquez-Soltero JM, Margolina A. BioMed Research International. 2014;2014:151479.
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways. BioMed Research International. 2015;2015:648108.
- Maquart FX, Pickart L, et al. Stimulation of collagen synthesis by GHK-Cu. FEBS Letters. 1988;238(2):343-346.
- Chang CH, et al. BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts. Molecules. 2014;19(12):19066-19077.
- Bock-Marquette I, et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration. Nature. 2004;432(7016):466-472.
- Sosne G, Qiu P, Goldstein AL, Wheater M. Biological activities of thymosin beta 4. The FASEB Journal. 2010;24(7):2144-2151.
- Bock-Marquette I, et al. International Immunopharmacology. 2023;116:109741.
- Canapp SO Jr, et al. Veterinary Surgery. 2003;32(6):515-523.
- Philp D, et al. Thymosin β4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair. Wound Repair and Regeneration. 2003;11(1):19-24.
- Staresinic M, et al. BPC 157 accelerates healing of transected rat Achilles tendon. Journal of Orthopaedic Research. 2003;21(6):976-983.
- Badenhorst T, et al. Effects of GHK-Cu on MMP and TIMP Expression. Journal of Aging Science. 2016;4(3):166.
- Smart N, et al. Nature. 2007;445(7124):177-182.
- Kuceki G, et al. JAAD International. 2025;20:38-40.
- Goldstein AL, et al. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends in Molecular Medicine. 2005;11(9):421-429.
- Sever M, et al. BPC 157 counteracts liver fibrosis. Journal of Physiology and Pharmacology. 2019;70(3):391-400.
- Shah R, et al. Oxidative Medicine and Cellular Longevity. 2018;2018:9630175.
- Sosne G, Dunn SP, Kim C. Cornea. 2015;34(5):491-496.
Preguntas de Investigación Relacionadas
Related research
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Este contenido se proporciona solo para fines educativos e informativos. Los productos se suministran exclusivamente para estudios in vitro y no son medicamentos, fármacos ni suplementos. No están aprobados por la FDA para prevenir, tratar o curar ninguna condición.