Visao Geral SS-31 (elamipretide) e um(a) sintetico(a), aromatic-cationic tetrapeptide pertencente a the Szeto-Schiller (SS) family of mitochondria-targeted peptides. Its sequence — D-Arg-Dmt-Lys-Phe-NH₂ — alternates cationic residues (D-Arg, Lys) with aromatic residues (Dmt, Phe), an architectural pattern que confere selective, high-affinity binding to cardiolipin (CL) no(a) inner membrana mitocondrial (IMM).[1][2] Discovery: SS-31 was identificado(a) serendipitously by Dr. Hazel Szeto (Weill Co

How does SS-31 work? What is its mechanism of action?

Mecanismo de Acao Primary Target: Cardiolipin (CL) no(a) Inner Mitochondrial Membrane SS-31 does NOT bind to a protein receptor. Instead, it binds directly to cardiolipin (CL) — an anionic phospholipid unique para o(a) IMM que is critico(a) para organizing the electron transport chain (ETC) into functional supercomplexes (respirasomes). The binding is driven by two forces:[1][2] Electrostatic: D-Arg and Lys (cationic residues) bind the anionic phosphate head groups of CL Hydrophobic: Dmt and Phe

What are the research applications of SS-31?

Aplicacoes de Pesquisa Elamipretide has been studied in cardiolipin and mitochondrial-membrane research; the published literature is listed under References. Aged-mouse model: exercise-tolerance endpoint reported (Campbell 2019).[4]

What does the research summary say about SS-31?

Preclinical & Clinical Research Summary Key Preclinical Studies EstudoModeloPrincipais AchadosRef Sabbah et al. (2016)Dogs, microembolization HF — 0.5 mg/kg × 3 moLVEF 30%→36% (p[6] Dai et al. (2013)C57BL/6 mice TAC — osmotic minipump × 4 wkFibrosis reduziu ~5% vs ~15% control (p=0.005); protegeu 84% of mitochondrial proteins[14] Campbell et al. (2019)Aged-mouse model (26-mo female C57BL/6)Exercise-tolerance endpoint reported[4] Chiao et al. (2020)Aged C57BL/6 mice — cardiac dysfunction modelLat

How should SS-31 be stored?

Pó liofilizado de grau de pesquisa. Armazene a -20 °C ou menos, dessecado, protegido da luz.

How to Store SS-31 — Storage & Handling Guide

Condições Recomendadas de Armazenamento Laboratorial

Research-Grade (Liofilizado Powder): Store at -20°C to -80°C in desiccated, airtight container. Estável à temperatura ambiente for limited time during shipping.

Solubilidade: solúvel em água. Dados de estabilidade em solução: consulte a literatura citada.

Formas de sal: acetato ou HCl.

Storing SS-31: Best Practices

Condições Recomendadas de Armazenamento Laboratorial

Referencias

Perguntas de Pesquisa Relacionadas

Related research

Storing SS-31: Best Practices

Condições Recomendadas de Armazenamento Laboratorial

Referencias

Perguntas de Pesquisa Relacionadas

Related research