Melanotan II vs Kisspeptina: Comparacao de Peptideos Neuroendocrinos
Quick Summary
Melanotan II e Kisspeptina modulam a sinalizacao neuroendocrina por vias distintas. Melanotan II e um agonista nao seletivo do receptor de melanocortina que afeta a pigmentacao da pele e o comportamento reprodutivo. Kisspeptina atua como regulador mestre do eixo hipotalamico-hipofisario-gonadal (HPG), controlando a atividade dos neuronios de GnRH. Ambos sao extensivamente estudados em biologia reprodutiva e neuroendocrinologia.
Melanotan II
Visao Geral Melanotan II (MT-II) e um(a) sintetico(a), cyclic heptapeptide analog do(a) endogenous 13-amino-acid hormone α-melanocyte-stimulating hormone (α-MSH). It was originally synthesized no(a) University of Arizona no(a) late 1980s by Victor Hruby, Mac Hadley, and Robert Dorr.[1] Chemically, MT-II is...
Kisspeptina
Visao Geral Kisspeptin refers to a family of neuropeptides derivado(a) de the KISS1 gene, originally descoberto(a) em 1996 by Danny R. Welch and J.H. Lee in Hershey, Pennsylvania, como um(a) melanoma metastasis suppressor. The gene was named "KiSS-1" to honor...
Research Comparison: Melanotan II vs Kisspeptina
| Dimension | Melanotan II | Kisspeptina |
|---|---|---|
| Estrutura | Heptapeptideo ciclico (7 aminoacidos, ponte lactama) | Kisspeptina-54 ou fragmentos menores (-10, -13, -14) |
| Alvos de Receptor | MC1R, MC3R, MC4R, MC5R (melanocortina nao seletivo) | KISS1R (GPR54) — altamente seletivo |
| Mecanismo Primario | Agonismo do receptor de melanocortina → melanogenese, funcao sexual | Estimulacao de neuronios de GnRH → liberacao pulsatil de LH/FSH |
| Efeitos na Pele | Desfechos de melanogenese (pigmentacao) | Nenhum |
| Resposta de LH/FSH | Indireta, aumento leve via vias centrais | Direta, estimulacao potente de GnRH → liberacao de LH/FSH |
| Origem do Desenvolvimento | Universidade do Arizona (Hruby/Hadley, anos 1990) | Descoberta em 2001 (Seminara/de Roux), multiplas instituicoes |
Chemical Properties Comparison
| Property | Melanotan II | Kisspeptina |
|---|---|---|
| Molecular Formula | C₅₀H₆₉N₁₅O₉ | — |
| Molecular Weight | 1024.18 Da | — |
| CAS Number | 121062-08-6 | — |
| Amino Acid Sequence | Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ | — |
| PubMed Citations | 24 referenced | 30 referenced |
Explore Full Research Profiles
Melanotan II
Visao Geral Melanotan II (MT-II) e um(a) sintetico(a), cyclic heptapeptide analog do(a) endogenous 13-amino-acid hormone α-melanocyte-stimulating hormone (α-MSH). It was originally synthesized no(a) University of Arizona no(a) late 1980s by Victor Hruby, Mac Hadley, and Robert Dorr.[1] Chemically, MT-II is...
Kisspeptina
Visao Geral Kisspeptin refers to a family of neuropeptides derivado(a) de the KISS1 gene, originally descoberto(a) em 1996 by Danny R. Welch and J.H. Lee in Hershey, Pennsylvania, como um(a) melanoma metastasis suppressor. The gene was named "KiSS-1" to honor...
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Educational Scope. This comparison summarizes published preclinical and clinical literature for research reference only. It is not medical advice, a recommendation, or guidance for in-human use, and the clinical studies cited were not conducted with the research-grade material supplied by Pure U.S. Peptides. Products are for laboratory research use only.