Visao Geral MOTS-c (Mitochondrial Open Reading Frame do(a) 12S rRNA-c) is a 16-amino-acid bioactive peptide pertencente a the class of mitochondrial-derived peptides (MDPs).[1] Unique origin: Diferentemente de virtually all outro(a) bioactive peptides codificado(a) por the nuclear genome, MOTS-c is encoded dentro do(a) mitochondrial genome (mtDNA) — specifically by a short open reading frame (sORF) dentro do(a) mitochondrial 12S rRNA gene (MT-RNR1). Apesar de being mtDNA-encoded, MOTS-c is trans

How does MOTS-c work? What is its mechanism of action?

Mecanismo de Acao Primary Pathway: Folate → AICAR → AMPK ("Master Metabolic Switch") MOTS-c inibe the folate cycle at 5-methyltetrahydrofolate (5Me-THF), blocking de novo purine biosynthesis. This leads to accumulation of AICAR (5-aminoimidazole-4-carboxamide ribonucleotide), que mimics AMP and ativa diretamente AMPK.[1] MOTS-c → inibe folate cycle (5Me-THF) Blocked purine synthesis → AICAR accumulation AICAR (AMP mimetic) → direto(a) AMPK ativacao AMPK → ACC fosforilacao → fatty acid oxidation

What are the research applications of MOTS-c?

Aplicacoes de Pesquisa MOTS-c research spans metabolic, aging, exercise-physiology, immunology and bone models: Metabolic Models — Diet-induced-obesity mouse model: body-weight and insulin-sensitivity endpoints reported (Lee 2015); T1D, T2D and gestational diabetes models also studied.[1][8] Exercise Physiology — Aged-mouse model (22 months): exercise-capacity endpoints reported; skeletal-muscle MOTS-c levels measured during exercise in humans (n=10).[2] Aging Biology — Endogenous levels decline

What does the research summary say about MOTS-c?

Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Lee et al. (2015)CD-1/C57BL/6 mice HFD — 0.5 mg/kg/day × 8 wkPrevented HFD-induziu obesidade (p[1] Reynolds et al. (2021)22-mo C57BL/6N mice — 15 mg/kg/dayRan 2-fold longer (p=0.000002), 2.16× farther; 100% reached final sprint at 15 mg/kg (vs 16.6% control)[2] Kong et al. (2021)NOD mice (T1D) — 0.5 mg/kg/day from 7 wk0% incidence at 19 wk vs 100% control; glicose sanguinea 251±140 vs 547±90 mg/dL; Treg prom

How should MOTS-c be stored?

Solúvel em água ou ácido acético diluído. Armazene o liofilizado a -20 °C ou menos, dessecado. Significativa instabilidade plasmática (~25% perda a 4°C/24h, 85–90% a RT em 2–3h).

Storing MOTS-c: Best Practices

$107.10 · COA do lote publicado · Água BAC grátis + frete grátis nos EUA · Despacho no mesmo dia antes das 14h ET · APENAS PARA USO EM PESQUISA

Comprar peptídeo MOTS-C 40mg

24 Citacoes PubMedRevisado por EspecialistasUltima Revisao: fevereiro de 2026

Condições Recomendadas de Armazenamento Laboratorial

Liofilizado Powder: Store in dry, cool, dark container at -18°C to -80°C, desiccated. Estável à temperatura ambiente for short periods (days) during shipping.

Solubilidade: solúvel em água ou ácido acético diluído.

Stability: Plasma levels decrease ~25% at 4°C/24h and 85–90% at room temperature within 2–3 hours.

Forms: Liofilizado white powder in sealed vials (typically 10 mg); research-grade.

Handling: Allow vials to warm to room temperature before opening para prevenir moisture condensation.

Editorial Research Note

“Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Lee et al.”

Pure U.S. Peptides Research Standards TeamInternal editorial group summarising published peptide research for an audience of qualified independent investigators.

Referencias

Perguntas de Pesquisa Relacionadas

→ What Is MOTS-c?→ MOTS-c: Mechanism of Action → MOTS-c: Research Applications → MOTS-c: Safety Profile & Research Summary → MOTS-c: Chemical Properties

Related research

NAD+ — Storage & handling 5-Amino-1MQ — Storage & handling Epithalon — Storage & handling

Browse all research guides in the Peptide Research Library →

Deseja a revisao completa da pesquisa?

Comprar peptídeo MOTS-C 40mg→

APENAS PARA USO EM PESQUISA

Este conteudo e fornecido apenas para fins educacionais e informativos. Os produtos sao fornecidos apenas para estudos in vitro e nao sao medicamentos, drogas ou suplementos. Nao aprovado pela FDA para prevenir, tratar ou curar qualquer condicao.