Overview GLP3-R is the catalog designation for retatrutide (LY3437943), a synthetic peptide characterized in the peer-reviewed literature as a single-molecule agonist at three receptors: GIP, GLP-1, and glucagon.[1] Coskun and colleagues published the discovery-to-proof-of-concept characterization in Cell Metabolism, and Urva et al. reported the first multiple-ascending-dose clinical pharmacology study in The Lancet.[1][2] What distinguishes this compound within the incretin literature is the th

How does GLP3-R work? What is its mechanism of action?

Reported Mechanism 1. Triple Receptor Engagement Retatrutide is described as engaging three class-B G-protein-coupled receptors with a single peptide sequence: the GIP receptor, the GLP-1 receptor, and the glucagon receptor.[1] This distinguishes it from dual GIP/GLP-1 agonism and from GLP-1-selective agonism, and it is the structural feature that defines the compound's research role.[8] 2. Incretin-Axis Signalling GLP-1 and GIP receptor agonism act on the incretin axis, where insulinotropic act

What are the research applications of GLP3-R?

Research Applications Published literature (all studies used the pharmaceutical formulation), organised by mechanism: Receptor pharmacology — Coskun et al. reported the discovery-to-proof-of-concept work defining triple GIP/GLP-1/glucagon agonism.[1] Clinical pharmacology — phase 1b and phase 2 trials of the pharmaceutical formulation are listed under References.[2][3][4][5] Gastric-emptying pharmacodynamics — Urva et al. reported effects on gastric emptying.[6] Comparative incretin pharmacology

What does the research summary say about GLP3-R?

Research Summary Foundational Studies StudyTypeSubject of ReportRef Coskun et al. (2022)Discovery / proof of conceptCharacterization of LY3437943 as a triple glucagon, GIP, and GLP-1 receptor agonist[1] Urva et al. (2022)Phase 1b multiple-ascending-dose trialClinical pharmacology[2] Jastreboff et al. (2023)Phase 2Triple-hormone-receptor agonist evaluated in a phase 2 trial[3] Rosenstock et al. (2023)Phase 2Placebo- and active-controlled parallel-group trial[4] Sanyal et al. (2024)Phase 2a (MASLD

How should GLP3-R be stored?

Store lyophilized at -20°C for long-term storage, or 2-8°C short-term. Keep tightly sealed, protected from light and moisture.

GLP3-R: Chemical Properties

From $69.30 · Lot COAs published for 4 of 4 sizes · Free BAC water + free U.S. shipping · Same-day dispatch before 2 PM ET · FOR RESEARCH USE ONLY

Buy GLP3-R Peptide - all sizes

10 PubMed CitationsExpert ReviewedLast Reviewed: July 2026

Chemical Properties

Synonyms	Retatrutide, LY3437943, GLP3-R
Class	Synthetic acylated peptide; triple GIP / GLP-1 / glucagon receptor agonist
Structural Basis	Single peptide sequence engineered from an incretin backbone with a fatty-diacid conjugate supporting albumin binding, as described by Coskun et al. (2022)
Appearance	White-to-off-white lyophilized powder
Regulatory Status	Investigational — not approved by FDA or EMA for any indication
Classification	Research peptide

Identifiers

Development Code	LY3437943
Purity Standard	≥98% by HPLC
Identity Confirmation	Not reported on the published lot certificate
Detection Methods	RP-HPLC, LC-MS/MS

Editorial Research Note

“Research Summary Foundational Studies StudyTypeSubject of ReportRef Coskun et al.”

Pure U.S. Peptides Research Standards TeamInternal editorial group summarising published peptide research for an audience of qualified independent investigators.

References

Related research

Cagriniltide — Chemical properties GLP2-T — Chemical properties

Browse all research guides in the Peptide Research Library →

Want the complete research review?

Buy GLP3-R Peptide - all sizes→

FOR RESEARCH USE ONLY

This content is provided for educational and informational purposes only. Products are furnished for in-vitro studies only and are not medicines, drugs, or supplements. Not approved by the FDA to prevent, treat, or cure any condition.

GLP3-R: Chemical Properties

From $69.30 · Lot COAs published for 4 of 4 sizes · Free BAC water + free U.S. shipping · Same-day dispatch before 2 PM ET · FOR RESEARCH USE ONLY

Buy GLP3-R Peptide - all sizes

10 PubMed CitationsExpert ReviewedLast Reviewed: July 2026

Chemical Properties

Synonyms	Retatrutide, LY3437943, GLP3-R
Class	Synthetic acylated peptide; triple GIP / GLP-1 / glucagon receptor agonist
Structural Basis	Single peptide sequence engineered from an incretin backbone with a fatty-diacid conjugate supporting albumin binding, as described by Coskun et al. (2022)
Appearance	White-to-off-white lyophilized powder
Regulatory Status	Investigational — not approved by FDA or EMA for any indication
Classification	Research peptide

Identifiers

Development Code	LY3437943
Purity Standard	≥98% by HPLC
Identity Confirmation	Not reported on the published lot certificate
Detection Methods	RP-HPLC, LC-MS/MS

Editorial Research Note

“Research Summary Foundational Studies StudyTypeSubject of ReportRef Coskun et al.”

Pure U.S. Peptides Research Standards TeamInternal editorial group summarising published peptide research for an audience of qualified independent investigators.

References

Related research

Cagriniltide — Chemical properties GLP2-T — Chemical properties

Browse all research guides in the Peptide Research Library →

Want the complete research review?

Buy GLP3-R Peptide - all sizes→

FOR RESEARCH USE ONLY

GLP3-R: Chemical Properties

Chemical Properties

Identifiers

References

Related Research Questions

Related research

GLP3-R: Chemical Properties

Chemical Properties

Identifiers

References

Related Research Questions

Related research