Overview GLP-2 Analog (Teduglutide; ALX-0600) is a 33-amino-acid recombinant analog of human glucagon-like peptide-2 (GLP-2) originally engineered by Drucker and colleagues to extend the very short circulating half-life of native GLP-2 (~7 minutes) by substituting glycine for alanine at position 2, the canonical dipeptidyl-peptidase-IV (DPP-IV) cleavage site. The single Ala²Gly substitution renders the peptide resistant to N-terminal proteolysis while preserving full agonist activity at the GLP-

How does Tirzepatide work? What is its mechanism of action?

Mechanism of Action Primary Target: The GLP-2 Receptor (GLP-2R) Teduglutide acts as a full agonist at the GLP-2 receptor, a class B (secretin-family) Gαs-coupled GPCR expressed predominantly on intestinal sub-epithelial myofibroblasts, enteric neurons, and a subset of enteroendocrine cells. Receptor occupancy elevates intracellular cAMP and triggers downstream protein-kinase-A signaling, which has been mapped in primary cell and explant studies to (a) release of insulin-like growth factor-1 (IGF

What are the research applications of Tirzepatide?

Research Applications Teduglutide is studied in preclinical models that probe GLP-2R biology and intestinal-epithelial growth-control mechanisms. Reported research applications include: GLP-2R Pharmacology Profiling — Used as a high-affinity, DPP-IV-resistant agonist probe to characterize GLP-2R density, downstream cAMP/PKA coupling, and receptor desensitization kinetics in primary intestinal-fibroblast cultures, enteric-neuron preparations, and recombinant cell-line systems. The extended half-l

What does the research summary say about Tirzepatide?

Preclinical Research Summary Foundational Studies StudyModelKey FindingsRef Drucker et al. (1996)Glucagonoma xenograft miceFirst identification of GLP-2 intestinotrophic activity; small-bowel hyperplasia mapped to the 33-mer proglucagon-derived peptide[1] Drucker et al. (1997)Mouse pharmacokinetic / structure-activityAla²Gly substitution confers DPP-IV resistance; in-vivo half-life extended ~10× vs native GLP-2 with full agonist activity preserved[2] Munroe et al. (1999)GLP-2R cloning and charac

How should Tirzepatide be stored?

Store at 2–8°C (refrigerated). After reconstitution, use within 3 hours at room temperature. Do not freeze.

Tirzepatide: Chemical Properties

12 PubMed CitationsExpert ReviewedGMP CertifiedLast Reviewed: May 2026

Chemical Properties

Formula	C164H252N44O55S
Molecular Weight	3752.1 Da
Synonyms	Teduglutide, GLP-2 Analog, ALX-0600, Gattex, Revestive
Cas Number	197922-42-2
Sequence	His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp
Pubchem Cid	16133828
Monoisotopic Mass	N/A
Polar Area	N/A
Complexity	N/A
X Log P	N/A
Heavy Atom Count	N/A
H Bond Donor Count	N/A
H Bond Acceptor Count	N/A
Rotatable Bond Count	N/A

Identifiers

Pubchem Cid	16133828
Inchi Key	N/A
Inchi	N/A — 33-amino acid linear peptide
Smiles Isomeric	N/A — 33-AA peptide (full SMILES via PubChem CID 16133828)
Smiles Canonical	N/A — 33-AA peptide (full SMILES via PubChem CID 16133828)
Iupac Name	Teduglutide — 33-amino acid GLP-2 analog peptide with Gly2→Ala substitution

Expert Observation

“Preclinical Research Summary Foundational Studies StudyModelKey FindingsRef Drucker et al.”

Dr. Daniel J. DruckerDaniel J. Drucker, OC, MD, FRSC, is a Senior Investigator at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, and Professor of Medicine at the University of Toront…

References

Drucker DJ, Erlich P, Asa SL, Brubaker PL. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci USA. 1996;93(15):7911-7916.
Drucker DJ, Shi Q, Crivici A, et al. Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV. Nat Biotechnol. 1997;15(7):673-677.
Scott RB, Kirk D, MacNaughton WK, Meddings JB. GLP-2 augments the adaptive response to massive intestinal resection in rat. Am J Physiol. 1998;275(5):G911-G921.
Cheeseman CI, Tsang R. The effect of GIP and glucagon-like peptides on intestinal basolateral membrane hexose transport. Am J Physiol. 1996;271(3):G477-G482.
Munroe DG, Gupta AK, Kooshesh F, et al. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. Proc Natl Acad Sci USA. 1999;96(4):1569-1573.
Drucker DJ, Yusta B. Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2. Annu Rev Physiol. 2014;76:561-583.
Dubé PE, Forse CL, Bahrami J, Brubaker PL. The essential role of insulin-like growth factor-1 in the intestinal tropic effects of glucagon-like peptide-2 in mice. Gastroenterology. 2006;131(2):589-605.
Marier JF, Beliveau M, Mouksassi MS, et al. Pharmacokinetics, safety, and tolerability of teduglutide, a glucagon-like peptide-2 (GLP-2) analog, following multiple ascending subcutaneous administrations in healthy subjects. J Clin Pharmacol. 2008;48(11):1289-1299.
Boushey RP, Yusta B, Drucker DJ. Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis. Am J Physiol. 1999;277(5):E937-E947.
Burrin DG, Stoll B, Guan X, et al. Glucagon-like peptide 2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets. Endocrinology. 2005;146(1):22-32.
Prasad R, Alavi K, Schwartz MZ. Glucagon-like peptide-2 analogue enhances intestinal mucosal mass after ischemia and reperfusion. J Pediatr Surg. 2000;35(2):357-359.
Yusta B, Holland D, Koehler JA, et al. ErbB signaling is required for the proliferative actions of GLP-2 in the murine gut. Gastroenterology. 2009;137(3):986-996.

Tirzepatide: Chemical Properties

Chemical Properties

Identifiers

References

Related Research Questions

Tirzepatide: Chemical Properties

Chemical Properties

Identifiers

References

Related Research Questions