Ghk Cu Research Applications — Scientific Studies & Evidence

GHK-Cu research spans dermatology, wound healing, pulmonology, oncology, and neuroscience across 10+ indication categories:

Wound Healing & Tissue Regeneration — Accelerates contraction, re-epithelialization, collagen accumulation; reduces TNF-α and MMPs. 64.5% wound size reduction vs 28.2% control (Canapp et al., 2003).[11]
Dermatology & Anti-Aging — Tightens skin, improves elasticity/density/thickness; reduces wrinkles 55%; outperforms Vitamin C and retinoic acid for collagen production (70% vs 50% vs 40%).[12]
Hair Growth Stimulation — Enlarges follicle size, prolongs anagen phase; comparable to 5% minoxidil. MDCT approach: SALT score 40%→7.5%.[13]
COPD/Emphysema — Reverses emphysematous gene expression; restores TGF-β pathway in lung fibroblasts.[7]
Anti-Cancer & Metastasis Suppression — Connectivity Map identifies GHK as reverser of metastatic colon cancer gene signature; reactivates apoptosis in neuroblastoma/leukemia/breast cancer.[9]
DNA Repair & Radiation Recovery — Restores replicative vitality to irradiated fibroblasts; ↑ bFGF, VEGF.[14]
Antioxidant & Anti-Inflammatory — Neutralizes acrolein/4-HNE; blocks ferritin iron release (87% ↓ lipid peroxidation); suppresses NF-κB.[8]
Neuroprotection — Promotes nerve outgrowth; ↑ NGF, NT-3, NT-4; reduces anxiety/pain/aggression at 0.5 µg/kg.[15]
Bone Regeneration — Promotes reparative osteogenesis in fracture models at 0.5 µg/kg.[16]
Gastrointestinal Healing — 60% reduction in IBD severity (n=16); ulcerative colitis relief via SIRT1/STAT3 pathway.[6]

GHK-Cu research spans dermatology, wound healing, pulmonology, oncology, and neuroscience across 10+ indication categories:

Wound Healing & Tissue Regeneration — Accelerates contraction, re-epithelialization, collagen accumulation; reduces TNF-α and MMPs. 64.5% wound size reduction vs 28.2% control (Canapp et al., 2003).[11]
Dermatology & Anti-Aging — Tightens skin, improves elasticity/density/thickness; reduces wrinkles 55%; outperforms Vitamin C and retinoic acid for collagen production (70% vs 50% vs 40%).[12]
Hair Growth Stimulation — Enlarges follicle size, prolongs anagen phase; comparable to 5% minoxidil. MDCT approach: SALT score 40%→7.5%.[13]
COPD/Emphysema — Reverses emphysematous gene expression; restores TGF-β pathway in lung fibroblasts.[7]
Anti-Cancer & Metastasis Suppression — Connectivity Map identifies GHK as reverser of metastatic colon cancer gene signature; reactivates apoptosis in neuroblastoma/leukemia/breast cancer.[9]
DNA Repair & Radiation Recovery — Restores replicative vitality to irradiated fibroblasts; ↑ bFGF, VEGF.[14]
Antioxidant & Anti-Inflammatory — Neutralizes acrolein/4-HNE; blocks ferritin iron release (87% ↓ lipid peroxidation); suppresses NF-κB.[8]
Neuroprotection — Promotes nerve outgrowth; ↑ NGF, NT-3, NT-4; reduces anxiety/pain/aggression at 0.5 µg/kg.[15]
Bone Regeneration — Promotes reparative osteogenesis in fracture models at 0.5 µg/kg.[16]
Gastrointestinal Healing — 60% reduction in IBD severity (n=16); ulcerative colitis relief via SIRT1/STAT3 pathway.[6]

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