Overview BPC-157 (Body Protection Compound-157, Bepecin, PL 14736) is a synthetic pentadecapeptide composed of 15 amino acids (GEPPPGKPADDAGLV), derived from a partial sequence of a larger Body Protection Compound protein naturally found in human gastric juice.[1][2] Originally isolated by Dr. Predrag Sikiric's research group at the University of Zagreb in 1993, BPC-157 is one of the most extensively studied cytoprotective peptides in preclinical literature. It demonstrates pleiotropic effects a

How does BPC-157 work? What is its mechanism of action?

Mechanism of Action VEGFR2 Activation (Primary Target) BPC-157 binds to and activates vascular endothelial growth factor receptor 2 (VEGFR2) on endothelial cells. Unlike standard ligands, BPC-157 promotes VEGFR2 internalization — a critical step in activating downstream repair pathways.[7][10] Src Family Kinase Activation A 2025 study proposes that BPC-157 adopts a polyproline II helix structure that engages the SH3 domains of Src family kinases (c-Src, Yes, Fyn), relieving autoinhibition and ac

What are the research applications of BPC-157?

Research Applications BPC-157 demonstrates pleiotropic effects across multiple experimental paradigms, with unusually broad tissue coverage for a single peptide: Gastrointestinal Healing — Anti-ulcer peptidergic agent effective against IBD, ulcerative colitis, NSAID-induced lesions, and complex fistulas. Phase II human data available (n=53, ulcerative colitis).[6] Musculoskeletal Regeneration — Accelerated healing of transected/detached tendons (Achilles, quadriceps), ligaments (MCL), and skelet

What does the research summary say about BPC-157?

Preclinical Research Summary Key Preclinical Studies StudyModelKey FindingsRef He et al. (2022)SD rats / Beagle dogsPK study: IV t½ = 15.2 min (rats), 5.27 min (dogs); bioavailability 14-19% (rats IM), 45-51% (dogs IM); distributed to kidney, liver, stomach[26] Xu et al. (2020)Mice, rats, rabbits, dogsMulti-species toxicity: no LD1 achieved, no adverse signs at 20 mg/kg (rats) or 10 mg/kg (dogs)[9] Staresinic et al. (2003)Rats — Achilles transection10 µg/kg IP: improved AFI scores, increased loa

How should BPC-157 be stored?

BPC-157 is uniquely stable at room temperature. Standard recommendation: -20°C for long-term storage; reconstituted solutions at 2-8°C.

Storing BPC-157: Best Practices

30 PubMed CitationsExpert ReviewedGMP CertifiedLast Reviewed: May 2026

Recommended Laboratory Storage Conditions

Lyophilized Powder: BPC-157 is noted for being stable at room temperature — a distinct advantage over most thermolabile peptides. However, standard recommendation is -20°C (-4°F) for long-term storage to maximize shelf life.

Gastric Stability: Highly resistant to hydrolysis and enzymatic degradation in human gastric juice, remaining stable for >24 hours.

Reconstituted Solution: Refrigerate at 2–8°C (36–46°F). Use standard peptide handling protocols: reconstitute with bacteriostatic water or sterile saline.

Handling: Allow vial to reach room temperature before opening. Standard aseptic technique for all preparations. Discard any solution that appears cloudy or contains particulate matter.

Expert Observation

“Preclinical Research Summary Key Preclinical Studies StudyModelKey FindingsRef He et al.”

Dr. Predrag SikiricPredrag Sikiric, MD, PhD, is a Professor at the Department of Pharmacology, School of Medicine, University of Zagreb, Croatia. Dr.

Storing BPC-157: Best Practices

Recommended Laboratory Storage Conditions

References

Related Research Questions

Storing BPC-157: Best Practices

Recommended Laboratory Storage Conditions

References

Related Research Questions