How does Tesamorelin work? What is its mechanism of action?

1. Receptor Target — GHRH Receptor Tesamorelin acts como um(a) specific agonist para o(a) GHRH receptor (GHRHr), a seven-transmembrane G protein-coupled receptor (GPCR) located on somatotroph cells no(a) anterior pituitary gland. Binding potency is comparable to endogenous GHRH. [7] 2. DPP-4 Resistance The trans-3-hexenoic acid modification no(a) N-terminal Tyr1 acts como um(a) chemical shield against DPP-4 cleavage. Native GHRH is rapidamente degradado(a) (T½ ~5 min); Tesamorelin's modification

What are the research applications of Tesamorelin?

Tesamorelin is the active ingredient of an FDA-approved pharmaceutical (Egrifta). That approval does not apply to this research-grade material. Published literature is listed under References. Preclinical GH models: nerve-regeneration and muscle re-innervation endpoints reported. [14]

What does the research summary say about Tesamorelin?

Regulatory Context Tesamorelin is the active ingredient of an FDA-approved pharmaceutical (Egrifta). That approval does not apply to this research-grade material. Published literature is listed under References. Handling Safety Handle with standard laboratory PPE. Consult the SDS. TODOS OS ARTIGOS E INFORMAÇÕES SOBRE PRODUTOS FORNECIDOS NESTE SITE SÃO APENAS PARA FINS INFORMATIVOS E EDUCACIONAIS. Aviso sobre Estudos In Vitro / Pré-clínicos: Os achados de pesquisa descritos acima foram observados

How should Tesamorelin be stored?

Liofilizado: 2–8°C refrigerado, protegido da luz. Não congele.

What Is Tesamorelin?

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Resposta Rapida

Tesamorelin (TH9507) e um(a) sintetico(a) 44-aminoacido analog of endogenous GHRH with a peso molecular of 5135.9 Da. It foi desenvolvido(a) por Theratechnologies Inc. to overcome the inherent instability of native GHRH, que has a meia-vida of apenas 3–8 minutes due to rapido(a) cleavage by DPP-4. [...

Tesamorelin — Quick Facts

Chemical identity and reference data for Tesamorelin
Molecular formula	C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular weight	5135.9 Da g/mol
InChI key	VQFDKKWXORFBDI-VAVVJCQZSA-N
PubChem CID	16137828
Storage	Liofilizado: 2–8°C refrigerado, protegido da luz. Não congele.
Cited references	24

Chemical identity from PubChem CID 16137828. For research use only.

24 Citacoes PubMedRevisado por EspecialistasUltima Revisao: fevereiro de 2026

Tesamorelin (TH9507) e um(a) sintetico(a) 44-aminoacido analog of endogenous GHRH with a peso molecular of 5135.9 Da. It foi desenvolvido(a) por Theratechnologies Inc. to overcome the inherent instability of native GHRH, que has a meia-vida of apenas 3–8 minutes due to rapido(a) cleavage by DPP-4. [1] [2]

Key Structural Feature: A trans-3-hexenoic acid group is anchored para o(a) N-terminal tyrosine (Tyr1), rendering o peptideo resistant to DPP-4 degradacao and extending the meia-vida to aproximadamente 26–38 minutes. C-terminal is amidated (-NH₂). [3]

Regulatory Status:

FDA: Tesamorelin is the active ingredient of an FDA-approved pharmaceutical (Egrifta); that approval does not apply to this research-grade material. [4]
EMA: Application withdrawn; not marketed no(a) EU. [6]
WADA: Prohibited (S2 — Peptide Hormones, Growth Factors). [5]

Developer: Theratechnologies Inc. (Montreal, Canada) — originally designated TH9507.

Pharmacokinetic Highlights:

Half-Life: ~26–38 min
Pulsatility: Preserves natural pulsatile GH secretion (diferentemente de rhGH)

Editorial Research Note

“Aviso sobre Estudos In Vitro / Pré-clínicos: Os achados de pesquisa descritos acima foram observados em estudos laboratoriais (in vitro) e/ou em modelos animais.”

Pure U.S. Peptides Research Standards TeamInternal editorial group summarising published peptide research for an audience of qualified independent investigators.

Referencias

Perguntas de Pesquisa Relacionadas

→ Tesamorelin: Mechanism of Action → Tesamorelin: Research Applications → Tesamorelin: Safety Profile & Research Summary → Tesamorelin: Chemical Properties → Storing Tesamorelin: Best Practices

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Este conteudo e fornecido apenas para fins educacionais e informativos. Os produtos sao fornecidos apenas para estudos in vitro e nao sao medicamentos, drogas ou suplementos. Nao aprovado pela FDA para prevenir, tratar ou curar qualquer condicao.