How does Epithalon work? What is its mechanism of action?

Mecanismo de Acao Epithalon operates via a receptor-independent, epigenetic mechanism — bypassing cell surface receptors to directly interact com o(a) genome. It penetrates the cell nucleus and liga-se a DNA and histone proteins, functioning como um(a) master gene regulator.[3][1] Primary Epigenetic Targets TargetMecanismoDownstream Effect DNA — CAG repeats & ATTTC sequencesBinds principal groove of DNA double helixLowers chromatin melting temperature → previne genomic "hardening" with age Histo

What are the research applications of Epithalon?

Aplicacoes de Pesquisa Epithalon research spans 10+ indication categories with over 50 years of investigation (1970s–2025): Telomere Extension & Cellular Senescence — Cells surpass Hayflick limit; telomere elongation confirmou in subjects aged 60–80 (9.61→10.72 kb and 7.51→8.91 kb, p<0.05).[5] Cancer Prevention Paradox — Inhibits spontaneous tumors in HER-2/neu mice; reduz oncoexpressao genica 3.7-fold; anti-metastatic — apesar de telomerase ativacao.[7][14] Retinal Degeneration / Retinitis P

What does the research summary say about Epithalon?

Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Anisimov/Popovich et al. (2003)SHR mice — 1 µg/mouse SC × 5d/month from 3 moLast 10% lifespan aumentou 13.3%; chromosomal aberrations ↓17.1%; leukemia inibiu 6-fold[7] Anisimov et al. (2002)HER-2/neu camundongos transgenicos — 1 µg/mouse SC monthlyHER-2/neu mRNA reduziu 3.7-fold; breast adenocarcinoma incidence reduziu significativamente[14] Kossoy et al. (2006)C3H/He mice — 0.1 µg/mouse SC × 5x/wk × 6.5 moR

How should Epithalon be stored?

Armazene liofilizado a -20°C (anos-estável). Proteja da umidade e light. Reconstituído: 4°C até 20 dias; evite ciclos de congelamento-descongelamento.

What Is Epithalon?

Q: What is Epithalon?

Visao Geral da Pesquisa Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide geroprotector developed by Prof. Vladimir Khavinson no(a) St. Petersburg Institute of Bioregulacao and Gerontology como o(a) ativo(a) component of Epithalamin (bovine pineal gland extract). Its discovery originated from 1970s Soviet military research para proteger soldiers from radiation and acelerou aging.[4] Epithalon's mechanism is fundamentally diferente from classical receptor-ligand pharmacology. Rather do que

Q: What does the research summary say about Epithalon?

Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Anisimov/Popovich et al. (2003)SHR mice — 1 µg/mouse SC × 5d/month from 3 moLast 10% lifespan aumentou 13.3%; chromosomal aberrations ↓17.1%; leukemia inibiu 6-fold[7] Anisimov et al. (2002)HER-2/neu camundongos transgenicos — 1 µg/mouse SC monthlyHER-2/neu mRNA reduziu 3.7-fold; breast adenocarcinoma incidence reduziu significativamente[14] Kossoy et al. (2006)C3H/He mice — 0.1 µg/mouse SC × 5x/wk × 6.5 moR

Q: How should Epithalon be stored?

Armazene liofilizado a -20°C (anos-estável). Proteja da umidade e light. Reconstituído: 4°C até 20 dias; evite ciclos de congelamento-descongelamento.

Resposta Rapida

Visao Geral da Pesquisa Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide geroprotector developed by Prof. Vladimir Khavinson no(a) St. Petersburg Institute of Bioregulacao and Gerontology como o(a) ativo(a) component of Epithalamin (bovine pineal gland extract). Its discovery originated from ...

Revisado por EspecialistasCertificado GMP

Visao Geral da Pesquisa

Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide geroprotector developed by Prof. Vladimir Khavinson no(a) St. Petersburg Institute of Bioregulacao and Gerontology como o(a) ativo(a) component of Epithalamin (bovine pineal gland extract). Its discovery originated from 1970s Soviet military research para proteger soldiers from radiation and acelerou aging.[4]

Epithalon's mechanism is fundamentally diferente from classical receptor-ligand pharmacology. Rather do que binding a cell surface receptor, it enters the nucleus and interacts directly with DNA (targeting CAG repeats and ATTTC promoter sequences) and histone proteins (H1.3, H1.6) — functioning como um(a) epigenetic switch que converts heterochromatin to euchromatin, making silenced genes accessible for transcricao.[1][3]

Research spans 10+ indication categories across gerontology, oncology, ophthalmology, endocrinology, and neuroscience — with over 50 years of study (1970s–2025). The "Epithalon Paradox" — activating telomerase enquanto simultaneamente inhibiting cancer — challenges conventional oncological assumptions and remains a principal focus of current research.[7]

Editorial Research Note

“Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Anisimov/Popovich et al.”

Pure U.S. Peptides Research Standards TeamInternal editorial group summarising published peptide research for an audience of qualified independent investigators.

Perguntas de Pesquisa Relacionadas

→ Epithalon: Mechanism of Action → Epithalon: Research Applications → Epithalon: Safety Profile & Research Summary → Epithalon: Chemical Properties → Storing Epithalon: Best Practices

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