What Is Epithalon?
Resposta Rapida
Visao Geral da Pesquisa Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide geroprotector developed by Prof. Vladimir Khavinson no(a) St. Petersburg Institute of Bioregulacao and Gerontology como o(a) ativo(a) component of Epithalamin (bovine pineal gland extract). Its discovery originated from ...
Epithalon — Quick Facts
| Molecular formula | C14H22N4O9 |
|---|---|
| Molecular weight | 390.35 g/mol |
| InChI key | HGHOBRRUMWJWCU-FXQIFTODSA-N |
| PubChem CID | 219042 |
| Storage | Armazene liofilizado a -20°C (anos-estável). Proteja da umidade e light. Reconstituído: 4°C até 20 dias; evite ciclos de congelamento-descongelamento. |
Chemical identity from PubChem CID 219042. For research use only.
Visao Geral da Pesquisa
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide geroprotector developed by Prof. Vladimir Khavinson no(a) St. Petersburg Institute of Bioregulacao and Gerontology como o(a) ativo(a) component of Epithalamin (bovine pineal gland extract). Its discovery originated from 1970s Soviet military research para proteger soldiers from radiation and acelerou aging.[4]
Epithalon's mechanism is fundamentally diferente from classical receptor-ligand pharmacology. Rather do que binding a cell surface receptor, it enters the nucleus and interacts directly with DNA (targeting CAG repeats and ATTTC promoter sequences) and histone proteins (H1.3, H1.6) — functioning como um(a) epigenetic switch que converts heterochromatin to euchromatin, making silenced genes accessible for transcricao.[1][3]
Research spans 10+ indication categories across gerontology, oncology, ophthalmology, endocrinology, and neuroscience — with over 50 years of study (1970s–2025). The "Epithalon Paradox" — activating telomerase enquanto simultaneamente inhibiting cancer — challenges conventional oncological assumptions and remains a principal focus of current research.[7]
“Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Anisimov/Popovich et al.”
Perguntas de Pesquisa Relacionadas
Related research
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Ver Pagina Completa de Pesquisa de Epithalon→APENAS PARA USO EM PESQUISA
Este conteudo e fornecido apenas para fins educacionais e informativos. Os produtos sao fornecidos apenas para estudos in vitro e nao sao medicamentos, drogas ou suplementos. Nao aprovado pela FDA para prevenir, tratar ou curar qualquer condicao.