Storing VIP: Best Practices
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Comprar peptídeo VIP 10mg⚠️ Critical: VIP has an extremely short serum meia-vida of aproximadamente 1–2 minutes due to rapido(a) enzymatic degradacao by DPP-4 e outros(as) peptidases. Este peptideo is significantly mais labile do que a maioria outro(a) research peptides. Handle with care.
❄️ Liofilizado Powder Storage
Store liofilizado VIP at -20°C (−4°F) in a desiccated environment, protegeu from light. Under these conditions, the powder remains estável por extended periods. Do not subject to repeated freeze-thaw cycles.
🧴 Stability Considerations
VIP is rapidamente degradado(a) by dipeptidyl peptidase-4 (DPP-4) e outros(as) serum peptidases. Research delivery systems como sterically stabilized micelles (SSM), liposomes, and inhalation formulations are employed in preclinical and clinical settings to extend biodisponibilidade.
📊 Documentacao de qualidade
O certificado de lote deste produto está pendente. This product is apenas para uso em pesquisa (RUO).
“Estudos em Animais Parkinson’s Disease (Rats, Mosley 2019): VIPR2 agonist LBT-3627 at 2.0 mg/kg — 43% increase in surviving TH+ neurons (α-Syn model), 53% spared at 6.0 mg/kg (6-OHDA model), 57–61% reduction in reactive microglia.”
Referencias
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- Said SI, Rosenberg RN. Vasoactive intestinal polypeptide: abundant immunoreactivity in neuronal cell lines and normal nervous tissues. Science, 192(4242), 907–908, 1976.
- Langer I, Jeandriens J, Couvineau A, et al. Signal transduction by VIP and PACAP receptors. Biochem Soc Trans, 50(1), 2022.
- Youssef JG, Lavin P, Schoenfeld DA, et al. Crit Care Med, 50(11), 1545–1554, 2022.
- Domschke S, Domschke W, Bloom SR, et al. Vasoactive intestinal peptide in man: pharmacokinetics, metabolic and circulatory effects. Gut, 19(11), 1049–1053, 1978.
- Harmar AJ, Arimura A, Gozes I, et al. International union of pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol Rev, 50(2), 265–270, 1998.
- Leuchte HH, Baezner C, Baumgartner RA, et al. Eur Respir J, 32(5), 1289–1294, 2008.
- Delgado M, Pozo D, Ganea D. The significance of vasoactive intestinal peptide in immunomodulacao. Pharmacol Rev, 56(2), 249–290, 2004.
- Couvineau A, Laburthe M. VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins. Br J Pharmacol, 166(1), 42–50, 2012.
- Hou X, Yang H, Bhatt VR, et al. VIP/VPAC signaling in pancreatic islet β-cells and glucose homeostasis. J Mol Endocrinol, 68(3), R65–R75, 2022.
- Smalley SG, Barrow PA, Foster N. Immunomodulacao of innate resposta imunologicas by vasoactive intestinal peptide (VIP): its experimental potential in inflammatory disease. Clin Exp Immunol, 157(2), 225–234, 2009.
- Constantin S, Bhattarai JP, Bhatt R, et al. VIP signaling in GnRH neurons envolve dual Gs/AC and Gq/PLC pathways. J Neuroendocrinol, 36(4), e13392, 2024.
- Hou X, et al. VIP/VPAC signaling in pancreatic islet β-cells: PKA and Epac pathways drive dependente de glicose secrecao de insulina. J Mol Endocrinol, 2022.
- Moody TW, Nuche-Berenguer B, Jensen RT. Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, e seus(suas) receptors and cancer. Curr Opin Endocrinol Diabetes Obes, 23(1), 38–47, 2016.
- Mathioudakis AG, Chatzimavridou-Grigoriadou V, Evangelopoulou E, Mathioudakis GA. Hippokratia, 17(1), 12–16, 2013.
- Kudo T, Tahara Y, Gamble KL, et al. Vasoactive intestinal peptide produz long-lasting changes in neural activity no(a) suprachiasmatic nucleus. J Neurophysiol, 110(5), 1097–1106, 2013.
- Said SI. Vasoactive intestinal peptide no(a) lung. Ann N Y Acad Sci, 527, 450–464, 1988.
- An S, Tsai C, Bhatt R, et al. Vasoactive intestinal polypeptide phase-shifts the circadian clock via cAMP/PKA dependent pathway. J Biol Rhythms, 26(4), 313–326, 2011.
- Mosley RL, Lu Y, Olson KE, et al. Front Cell Neurosci, 13, 421, 2019.
- Brown SM, Barkauskas CE, Grund B, et al. Lancet Respir Med, 11(9), 791–803, 2023.
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- Jayawardena D, Guzman G, Gill RK, et al. Expression and localization of VPAC1, o(a) principal receptor of vasoactive intestinal peptide along the length do(a) intestine. Am J Physiol Gastrointest Liver Physiol, 313(1), G16–G25, 2017.
- Virgolini I, Raderer M, Kurtaran A, et al. Vasoactive intestinal peptide-receptor imaging para o(a) localization of intestinal adenocarcinomas and endocrine tumors. N Engl J Med, 331, 1116–1121, 1994.
- Zhang K, Aruva MR, Shanthly N, et al. PET imaging of VPAC1 expression in experimental and spontaneous prostate cancer. J Nucl Med, 49(1), 112–121, 2008.
- Prasse A, Zissel G, Lützen N, et al. Am J Respir Crit Care Med, 182(4), 540–548, 2010.
- Youssef JG, Said SI, et al. Preprints, 2020.
- Esendagli D, Sarı N, Akhan S, et al. Med Princ Pract, 34(2), 191–200, 2025.
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Comprar peptídeo VIP 10mg→APENAS PARA USO EM PESQUISA
Este conteudo e fornecido apenas para fins educacionais e informativos. Os produtos sao fornecidos apenas para estudos in vitro e nao sao medicamentos, drogas ou suplementos. Nao aprovado pela FDA para prevenir, tratar ou curar qualquer condicao.