Storing FOXO4-DRI: Best Practices
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Comprar peptídeo FOXO4 10mg (FOXO4-DRI)Pó Liofilizado
Store at -20°C or lower para manter stability. The liofilizado form is highly estavel due to D-aminoacido composition. Keep sealed, away from moisture and light.
Solubilidade
Solúvel em PBS ou água estéril.
Manuseio
White liofilizado powder, typically supplied como um(a) TFA (trifluoroacetic acid) salt. Os certificados publicados informam a pureza por HPLC e as endotoxinas quando testadas. The D-Retro-Inverso modification provides exceptional resistance to proteolytic degradacao, with intracellular detection até 72 hours post-administration.
“Resumo da Pesquisa Pre-clinica Key Preclinical Animal Studies EstudoModeloPrincipais AchadosRef Baar et al.”
Referencias
- Baar MP, et al. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell, 169(1), 132-147.e16, 2017.
- Bourgeois B, et al. The disordered p53 transativacao domain e o(a) target of FOXO4 e o(a) senolytic compound FOXO4-DRI. Nature Communications, 16(1), 5672, 2025.
- Bourgeois B, Madl T. Regulation of cellular senescencia via o(a) FOXO4-p53 axis. FEBS Letters, 592(12), 2083-2097, 2018.
- Zhang C, et al. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in camundongos idosos. Aging, 12(2), 1272-1284, 2020.
- Hu Z, et al. FOXO4-DRI regula celula endotelial senescencia via o(a) P53 via de sinalizacao. Frontiers in Bioengineering and Biotechnology, 13, 1729166, 2026.
- Huang Y, et al. Frontiers in Bioengineering and Biotechnology, 9, 677576, 2021.
- Li Y, et al. FOXO4-DRI melhora spermatogenesis in camundongos idosos through reducing senescencia-associated secretory phenotype secretion from Leydig cells. Experimental Gerontology, 195, 112522, 2024.
- Han X, et al. FOXO4 peptide direciona myofibroblaspara melhorars bleomycin-induziu pulmonar fibrose in mice through ECM-receptor interaction pathway. Journal of Cellular and Molecular Medicine, 26(11), 3269-3280, 2022.
- Liu Y, et al. FOXO4-D-Retro-Inverso direciona matriz extracelular production in fibroblastos and melhora bleomycin-induziu pulmonar fibrose in mice. Naunyn-Schmiedeberg's Archives of Pharmacology, 396(10), 2393-2403, 2023.
- Putavet DA, et al. Cancer Research, 81(5_Supplement), IA002, 2021.
- Meng J, et al. Targeting senescencia-like fibroblastos radiosensitizes non-small cell lung cancer and reduz radiation-induziu pulmonar fibrose. JCI Insight, 6(23), e146334, 2021.
- Krimpenfort P, Berns A. Cell, 169(1), 3-5, 2017.
- Mandal R, et al. FOXO4 interage com p53 TAD and CRD and inibe its binding to DNA. Protein Science, 31(5), e4287, 2022.
- Kong YX, et al. FOXO4-DRI induz keloid senescent fibroblasto apoptose by promoting nuclear exclusion of upregulou p53-serine 15 fosforilacao. Communications Biology, 8(1), 299, 2025.
- van Willigenburg H, de Keizer PLJ, de Bruin RWF. Pharmacological Research, 130, 322-330, 2018.
- Putavet D, et al. Abstract P1-19-02: Repurposing the FOXO4 senolytic against triple-negative breast cancer. Cancer Research, 82(4_Supplement), P1-19-02, 2022.
- Nwankwo N, Okafor I. Bioinformatics procedure for investigating senolytic (anti-envelhecimento) agents: A digital signal processing technique. Aging Medicine, 6(4), 338-346, 2024.
- Timucin E, et al. Novel Senolytic Peptides. United States Patent Application, US20200255489A1, 2020.
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Comprar peptídeo FOXO4 10mg (FOXO4-DRI)→APENAS PARA USO EM PESQUISA
Este conteudo e fornecido apenas para fins educacionais e informativos. Os produtos sao fornecidos apenas para estudos in vitro e nao sao medicamentos, drogas ou suplementos. Nao aprovado pela FDA para prevenir, tratar ou curar qualquer condicao.