What is Cagriniltide?

Visao Geral da Pesquisa Cagriniltide (AM833/NN1213) is a long-acting acylated analogue of human amylin — a 37-aminoacido pancreatic hormone co-secreted with insulin que regula satiety and glucose homeostasis. Native human amylin is unstable, prone to amyloid fibril formation, and has a muito short meia-vida. The first-generation analogue, pramlintide, requer multiplas administracoes diarias.[2] Cagriniltide overcomes these limitations through C20 fatty diacid acylation (via γ-glutamic acid space

How does Cagriniltide work? What is its mechanism of action?

Mecanismo de Acao Cagriniltide functions como um(a) non-selective dual agonist of ambos(as) calcitonin receptors (CTR) and amylin receptors (AMY1R, AMY2R, AMY3R) — heterodimers of CTR with RAMPs 1, 2, or 3.[3][12] Receptor Targets & Binding TargetInteractionEvidence Calcitonin Receptor (CTR)Non-selective agonist; class B1 GPCR; EC50 62 pMKruse et al. (2021); Cao et al. (2025) cryo-EM[3][9] AMY1R (CTR+RAMP1)Potent agonist; "bypass" conformation bindingRAMP1/3 KO abolishes the anorectic response (

What are the research applications of Cagriniltide?

Aplicacoes de Pesquisa Published literature (clinical trials used the pharmaceutical formulation; see References) covers: Receptor Pharmacology — Cryo-EM structural biology of dual AMYR/CTR agonism; RAMP-dependent signaling; "bypass" vs "CT-like" receptor conformations; rapid-dissociation kinetics preventing dessensibilizacao.[9][10]

What does the research summary say about Cagriniltide?

Resumo da Pesquisa Pre-clinica Key Preclinical Studies EstudoModeloPrincipais AchadosRef Carvas et al. (2025)129S2/SvEv mice — WT vs RAMP1/3 KO; 3–300 nmol/kg30 nmol/kg: 24h food intake ↓51%; 57% fewer AP neurons ativou in KO[8] Kruse et al. (2021)Male SD rats — 0.1–30 nmol/kg; PK: 10 nmol/kgFood intake reduziu for varios(as) days at 1–10 nmol/kg; T½ 20–27h[3] Dahl et al. (2024)Rats — 30 nmol/kg single administrationFood intake reduziu 85% at 0–24h and 84% at 24–48h; EC50: hAMY3R 49 pM, hCTR 62

How should Cagriniltide be stored?

Liofilizado: -80°C (2 anos) ou -20°C (1 ano), vedado e protegido da luz e da umidade.

Cagriniltide Research Applications — Scientific Studies & Evidence

Aplicacoes de Pesquisa

Published literature (clinical trials used the pharmaceutical formulation; see References) covers:

Receptor Pharmacology — Cryo-EM structural biology of dual AMYR/CTR agonism; RAMP-dependent signaling; "bypass" vs "CT-like" receptor conformations; rapid-dissociation kinetics preventing dessensibilizacao.[9][10]

Cagriniltide: Research Applications

Aplicacoes de Pesquisa

Referencias

Perguntas de Pesquisa Relacionadas

Related research

Cagriniltide: Research Applications

Aplicacoes de Pesquisa

Referencias

Perguntas de Pesquisa Relacionadas

Related research