TB-500: Research Applications

Research Applications

In laboratory research, TB-500 and its parent molecule Tβ4 are investigated in multiple experimental paradigms:

1. Dermal Wound Healing — Accelerated repair of full-thickness dermal wounds in diabetic (db/db) and aged mouse models. Promoted keratinocyte migration, collagen deposition, and reduced scar tissue formation.[8][18]
2. Corneal Repair and Dry Eye — Improved signs and symptoms of moderate-to-severe dry eye and neurotrophic keratopathy. Promoted corneal epithelial cell migration and reduced ocular inflammation. Demonstrated efficacy in healing corneal defects from chemical burns and ethanol exposure.[19][20]
3. Cardiovascular Models — In myocardial ischemia models, reduced infarct size, preserved cardiac function, and promoted angiogenesis. Facilitated mobilization and differentiation of epicardial progenitor cells.[11][21]
4. Musculoskeletal Recovery — Investigated for accelerating muscle, tendon, and ligament injury recovery. Promoted myoblast migration and tenocyte proliferation in tendon transection models.[22]
5. Neuroprotection and CNS Repair — Neuroprotective in models of traumatic brain injury, stroke, and multiple sclerosis. Promoted oligodendrocyte differentiation and remyelination. Suppressed Toll-like receptor pro-inflammatory signaling.[23]
6. Liver and Kidney Fibrosis — Attenuated liver fibrosis and acute liver injury (ethanol/CCl₄ models) by suppressing oxidative stress, blocking NF-κB, and inhibiting hepatic stellate cell activation.[24][25]
7. Hair Growth — The actin-binding domain (TB-500 region) has been identified as an active site for promoting hair growth in preclinical models.[3]