Overview PT-141 is the catalog designation for bremelanotide, a synthetic cyclic heptapeptide lactam described in the peer-reviewed literature as a non-selective agonist at the melanocortin receptor family.[1] Molinoff and colleagues published the original characterization of the compound as a melanocortin agonist in Annals of the New York Academy of Sciences.[1] The molecule derives from the melanotropin structure-activity programme conducted at the University of Arizona, reviewed by Hadley and

How does PT-141 work? What is its mechanism of action?

Reported Mechanism 1. Melanocortin Receptor Engagement Bremelanotide is described as a non-selective agonist across the melanocortin receptor family — MC1R, MC3R, MC4R and MC5R — all members of the rhodopsin-like (class A) GPCR superfamily.[1][5] Reported potency is graded rather than subtype-selective, which is the property that makes the compound useful as a broad-spectrum reference ligand and, equally, the property that requires selective antagonists to be co-applied when a single subtype is

What are the research applications of PT-141?

Research Applications Published investigations involving bremelanotide fall into the following areas of laboratory and clinical research. These describe the subject matter of the published record and are not statements of effect. Melanocortin receptor pharmacology — Molinoff et al. published the original characterization of the compound as a melanocortin agonist, and Yuan and Tao reviewed the broader ligand landscape for these receptors.[1][5] MC4R structural biology — Zhang et al. resolved liga

What does the research summary say about PT-141?

Research Summary Foundational and Mechanistic Studies StudyTypeSubject of ReportRef Molinoff et al. (2003)Compound characterizationOriginal description of PT-141 as a melanocortin agonist[1] Van der Ploeg et al. (2002)Receptor genetics / pharmacologyIdentification of an MC4R role in centrally mediated melanocortin pharmacology[3] Hadley & Dorr (2006)Historical reviewMelanocortin peptide development programme and its milestones[2] Zhang et al. (2021)Structural biology (cryo-EM)Ligand recognit

How should PT-141 be stored?

Store lyophilized desiccated at -20 °C, protected from light.

Storing PT-141: Best Practices

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Comprar péptido PT-141 10mg (Bremelanotide)

24 Citas PubMedRevisado por EspecialistasÚltima Revisión: julio de 2026

Lyophilized Peptide Storage

Store the lyophilized powder desiccated at -20°C or below for long-term stability, protected from light and moisture. The material is supplied as a white lyophilized powder and is hygroscopic — keep tightly sealed and allow vials to reach room temperature before opening to limit condensation.

Stability

Published stability work on this compound characterizes its degradants and epimerization behaviour by LC-HRMS/MS, underscoring the importance of controlled storage for analytical reproducibility.

Handling Precautions

Handle using standard laboratory technique with appropriate personal protective equipment. Published certificates report HPLC purity and endotoxin where tested.

Editorial Research Note

“Research Summary Foundational and Mechanistic Studies StudyTypeSubject of ReportRef Molinoff et al.”

Pure U.S. Peptides Research Standards TeamInternal editorial group summarising published peptide research for an audience of qualified independent investigators.

Referencias

Preguntas de Investigación Relacionadas

→ What Is PT-141?→ PT-141: Mechanism of Action → PT-141: Research Applications → PT-141: Safety Profile & Research Summary → PT-141: Chemical Properties

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