Sermorelin: Research Applications
$53.55 · COA do lote publicado · Água BAC grátis + frete grátis nos EUA · Despacho no mesmo dia antes das 14h ET · APENAS PARA USO EM PESQUISA
Comprar peptídeo Sermorelin 10mg👶 Pediatric GHD (Formerly FDA-registered)
The Geref International Study Group multicenter trial (n=110) studied Sermorelin in pediatric GH deficiency, with growth-velocity, IGF-1 and glucose endpoints reported. [2]
🔬 Diagnostic Evaluation
A single IV dose (1 µg/kg) is used to assess pituitary GH reserve, distinguishing hypothalamic vs pituitary causes of GHD. Fewer false positives comparado(a) a outro(a) provocative tests. [2]
🧓 Age-Related GH Decline
A secreção de GH foi estudada em adultos mais velhos; alterações de IGF-1 foram relatadas em homens de 60–78 anos. [7] [12]
🧠 Cognitivo Function & Sleep
Sermorelin facilita slow-wave sleep, que is correlated with nocturnal GH secretion. Modulates age-related decline no(a) somatotropic axis. [13]
🛡️ Immunosenescencia
In aging adults, B-cell, T-cell-responsiveness, IL-2-receptor and immunoglobulin endpoints were reported. [11]
💪 Body Composition / Hypogonadal Men
A retrospective study (n=14) of hypogonadal men on testosterone + Sermorelin/GHRP-2/GHRP-6 reported IGF-1 endpoints at 90, 180, and 270 days; lean-body-mass and visceral-fat endpoints were also reported. [14]
🎯 Oncology — Glioma
Bioinformatics screening of 4,865 drugs identificado(a) Sermorelin como o(a) most eficaz candidate for recurrent glioma (P<0.0001). In vitro, it inibiu U87/LN229 cell growth dose-dependentely by blocking cell cycle and negatively regulating immune checkpoints. [10]
“Clinical Studies 🏛️ Sermorelin e o(a) classic GHRH fragment — formerly FDA-registered, with a robust tolerability record spanning pediatric, geriatric, and diagnostic applications.”
Referencias
- Chang Y, Huang R, Zhai Y, et al. Ann Transl Med, 9(5), 406, 2021.
- Prakash A, Goa KL. BioDrugs, 12(2), 139-157, 1999.
- Walker RF. Clin Interv Aging, 1(4), 307-308, 2006.
- Food and Drug Administration. Fed Register, 78(42), 14095-14096, 2013.
- Sinha DK, Balasubramanian A, Tatem AJ, et al. Transl Androl Urol, 9(Suppl 2), S149-S159, 2020.
- Grossman AB, Savage MO, Lytras N, Besser GM. Clin Endocrinol (Oxf), 21(3), 321-330, 1984.
- Corpas E, Harman SM, Piñeyro MA, et al. J Clin Endocrinol Metab, 75(2), 530-535, 1992.
- Heiman ML, Nekola MV, Murphy WA, Lance VA, Coy DH. An extremely sensitive in vitro model for elucidating structure-activity relationships of hormonio do crescimento-releasing factor analogs. Endocrinology, 116(1), 410-415, 1985.
- Gelander L, Lindstedt G, Selstam G, et al. Horm Res, 31(5-6), 213-220, 1989.
- Khorram O, Laughlin GA, Yen SS. J Clin Endocrinol Metab, 82(5), 1472-1479, 1997.
- Khorram O, Yeung M, Vu L, Yen SS. J Clin Endocrinol Metab, 82(11), 3590-3596, 1997.
- Vittone J, Blackman MR, Busby-Whitehead J, et al. Metabolism, 46(1), 89-96, 1997.
- Vitiello MV, Schwartz RS, Moe KE, Mazzoni G, Merriam GR. Dialogues Clin Neurosci, 3(3), 229-236, 2001.
- Sigalos JT, Pastuszak AW, Allison A, et al. Am J Mens Health, 11(6), 1752-1757, 2017.
- Schally AV, Wang H, He J, et al. PNAS, 115(47), 12028-12033, 2018.
- Jaszberenyi M, Rick FG, Popovics P, et al. Potentiation of cytotoxic chemotherapy by hormonio do crescimento-releasing hormone agonists. PNAS, 111(2), 781-786, 2014.
- Soule SG, King JA, Millar RP. J Clin Endocrinol Metab, 79(4), 1208-1211, 1994.
- Merriam GR, Buchner DM, Prinz PN, Schwartz RS, Vitiello MV. Potential applications of GH secretagogs no(a) evaluation and investigation do(a) age-related decline in GH secretion. Endocrine, 7(1), 49-52, 1997.
- Walker RF, Yang SW, Bercu BB. Robust Growth Hormone (GH) secretion in aged female rats co-administered GH-releasing hexapeptide (GHRP-6) and GH-releasing hormone (GHRH). Life Sci, 49(20), 1499-1504, 1991.
- Rafferty B, Coy DH, Poole S. Pharmacokinetic evaluation of superactive analogues of hormonio do crescimento-releasing factor (1-29)-amide. Peptides, 9(1), 207-209, 1988.
Perguntas de Pesquisa Relacionadas
Related research
Deseja a revisao completa da pesquisa?
Comprar peptídeo Sermorelin 10mg→APENAS PARA USO EM PESQUISA
Este conteudo e fornecido apenas para fins educacionais e informativos. Os produtos sao fornecidos apenas para estudos in vitro e nao sao medicamentos, drogas ou suplementos. Nao aprovado pela FDA para prevenir, tratar ou curar qualquer condicao.